The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Part I - Introduction/General Chapter 1: Aspects of the History and Nomenclature of Amyloid and Amyloidosis Per Westermark Chapter 2: Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis Mario Nuvolone, MD, PhD; Giovanni Palladini, MD, PhD; Giampaolo Merlini, MD Chapter 3: AA Amyloidosis Amanda K. Ombrello, MD; Ivona Aksentijevich, MD Chapter 4: Leukocyte cell-derived chemotaxin 2 Amyloidosis (ALECT2) Oana Madalina Mereuta, MD PhD; Chris P. Larsen, MD; Ahmet Dogan, MD PhD Chapter 5: The Hereditary Amyloidoses Merrill D. Benson, MD Chapter 6: Dialysis-Associated Amyloidosis Paweena Susantitaphong, MD; Laura M. Dember, MD; Bertrand L. Jaber, MD, MS Chapter 7: Localized amyloidoses and amyloidoses associated with aging outside the central nervous system Per Westermark Chapter 8: Amyloid Deposition in the Central Nervous System Fausto J. Rodriguez, Maria M. Picken, John M. Lee Part II - Non-Amyloid Protein Deposits Chapter 9: Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis Guillermo A. Herrera and Elba A. Turbat-Herrera Chapter 10: Light/Heavy Chain Deposition Disease as a Systemic Disorder Guillermo A. Herrera and Elba A. Turbat-Herrera Chapter 11: Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits Pierre Ronco, Alexandre Karras, and Emmanuelle Plaisier Chapter 12: Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond Maria M. Picken and Ahmet Dogan Part III - Diagnosis Chapter 13: Diagnosis of Amyloid Using Congo Red Alexander J. Howie Chapter 14: Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloidtype-specific Immunohistochemistry: A Review Reinhold P. Linke, MD, PhD Chapter 15: Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection Maria M. Picken and Guillermo A. Herrera Chapter 16: Fat tissue analysis in the management of patients with systemic amyloidosis Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg Chapter 17: Generic diagnosis of amyloid - a summary of current recommendations and the editor's comments on Chaps. 13-16 Maria M. Picken Chapter 18: Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloidtype-Specific Immunohistochemistry: A Review Reinhold P. Linke, MD, PhD Chapter 19: Amyloid Typing: Experience from a Large Referral Centre Janet A. Gilbertson, Julian D. Gillmore and Philip N. Hawkins Chapter 20: Options for amyloid typing in renal pathology - the advantages of frozen section immunofluorescence and a summary of general recommendations regarding immunohistochemistry methods Maria M. Picken Chapter 21: Amyloid typing in plastic embedded tissue by immune-gold-silver method Anne Raisanen-Sokolowski and Tom Tornroth Chapter 22: The Role of Immuno-electron Microscopy in Amyloid Typing: The Experience of the Pavia Referral Center Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Gian Luca Capello, Marco Paulli, and Giampaolo Merlini Chapter 23: Classification of amyloidosis by mass spectrometry-based proteomics Ahmet Dogan, MD, PhD Chapter 24: The Role of Differential Proteomics in Amyloid Typing: The Experience of the Pavia Referral Center Francesca Lavatelli, Francesca Brambilla, Andrea Di Fonzo, Giovanni Ferraro, Giovanni Palladini, Pierluigi Mauri and Giampaolo Merlini Part IV- Ancillary Studies of Amyloidosis Chapter 25: Laboratory Support for Diagnosis of Amyloidosis David L Murray, M.D., Ph.D. and Jerry A. Katzmann, Ph.D. Chapter 26: Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis John C. Lee, M.D., Lawreen H. Connors, Ph.D., Carl J. O'Hara, M.D. Chapter 27: Laboratory Methods for the Diagnosis of Hereditary Amyloidoses S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr. Part V- Organ Involvement in Amyloidoses Chapter 28: Amyloidoses of the Kidney, the Lower Urinary and Genital Tracts (male and female) and the Breast Maria M. Picken and Ahmet Dogan Chapter 29: Cardiac Amyloidosis Carmela D. Tan, M.D. and E. Rene Rodriguez, M.D. Chapter 30: Amyloidosis of the Gastrointestinal Tract and Liver Oscar W. Cummings, M.D., Merrill Benson, M.D. Chapter 31: Peripheral Nerve Amyloidosis Adam J. Loavenbruck, JaNean K. Engelstad, Christopher J. Klein Chapter 32: Amyloidosis of the Lymph Nodes and the Spleen Filiz Sen MD, Ahmet Dogan MD PhD Chapter 33: Amyloidosis of the lung Karen L. Grogg MD, Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD Chapter 34: Cutaneous Amyloidosis Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD Chapter 35: Iatrogenic pharmaceutical amyloidosis associated with insulin and enfuvirtide administration Ahmet Dogan MD PhD, Oana Madalina Mereuta MD PhD Part VI- Clinical Issues and Therapy Chapter 36: Clinical and pathologic issues in patients with amyloidosis - summary and practical comments regarding diagnosis, therapy and solid organ transplantation Maria M. Picken and Kevin Barton Chapter 37: Emerging Therapies for Amyloidosis Merrill D. Benson Chapter 38: Modern Therapies in AA Amyloidosis Amanda K. Ombrello, M.D. Chapter 39: Medicolegal Issues of Amyloidosis Timothy Craig Allen, M.D., J.D. Chapter 40: Amyloidosis from the Patient's Perspective Muriel Finkel