This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.
- Describes the role of OCT in evaluating disease progression in neurodegenerative disorders
- Covers a wide range of disorders
- Documents recent advances and explains their significance
Introduction.- OCT Technique – Past, Present and Future.- Optic Disc Edema.- Compressive Optic Neuropathy.- Multiple Sclerosis.- Parkinson’s Disease.- Alzheimer’s Disease.- Friedreichs Ataxia and More.- Other Neurological Disorders: Migraine, Neurosarcoidosis, Schizophrenia, Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS).- Hereditary Optic Neuropathies.- Trans Neuronal Retrograde Degeneration.- New OCT Technology in Neuro-Ophthalmology.- OCT and Pharmacological Treatment.- Animal Models in Neuro-Ophthalmology.- OCT in Glaucoma.- OCT in Amblyopia.- Conclusions.