This book focuses primarily on the most efficient way to make an accurate FNA
diagnosis of metastatic tumors within the broad confines of cytopathology. The
text provides a step-by-step "thought process" during the diagnostic
approach of the metastatic tumors using detailed algorithms. Starting from the
onsite immediate FNA sample assessment, the book provides strategy of specimen
triage to facilitate further cytology evaluation based on the metastatic patterns
and morphologic patterns of the tumors. In the subsequent chapter, the book
provides tips and traps of selecting markers and interpretation of immunoperoxidase,
flow cytometric, cytogenetic and molecular studies. The book includes the strategy
of dealing with limited FNA material and wisely use existing samples (cell block,
direct smear, cytospin) for different ancillary studies including molecular
tests that have been used at MD Anderson. The author highlights challenging
issues to show the importance of using a multidisciplinary (clinical, radiologic,
cytologic and ancillary studies) approach. Extensive illustrations are provided.
Metastatic Neoplasms in Fine-Needle Aspiration Cytology will provide pathology residents, fellows, practicing cytopathologists and cytotechnologists with a practical way to approach metastatic malignancies in daily cytology practice as well as provide a vision of the future of cytopathology.
Introduction.- Sample Collection, Preparation, Rapid Onsite Evaluation and Triage.- Morphologic Evaluation.- Immunoperoxidase Studies.- Flow Cytometric Immunophenotyping.- Cytogenetic Studies.- Molecular Studies.