This volume provides the most comprehensive coverage of clinical management of borderline resectable pancreatic cancer available. Authored by leaders in the field, the book focuses on current clinical management of this disease stage, the importance of multimodality treatment algorithms, and an interdisciplinary approach to care. Surgical chapters are well-illustrated to provide surgeons and surgical trainees with important technical pearls. Clinical trials and trial design are also discussed. Multimodality Management of Borderline Resectable Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, radiation oncologists, surgical oncologists, general surgeons, and trainees interested in the treatment of pancreatic cancer.
Part 1. Overview 1. Anatomic Definitions of Borderline Resectable Pancreatic Cancer Rebecca A. Snyder, Alexander A. Parikh, Kamran Idress, and Nipun B. Merchant Part 2. Staging and Pretreatment Management 2. Imaging Evaluation of Borderline Pancreatic Cancer Kyuran Ann Choe and Nicholas M. McDonald 3. Endoscopic Ultrasonography: Staging and Therapeutic Intervention Girish Mishra and Rishi Pawa 4. Endoscopic and Percutaneous Biliary Drainage Procedures: Role in Preoperative Management, Diagnosis, and Palliation Milton T. Smith Part 3. Multimodal Therapy 5. Overview of Multimodality Therapy Robert de Wilton Marsh and Marshall S. Baker 6. Role of Systemic Therapy Matthew J. Reilley and Gauri Varadhachary 7. Role of Radiation Therapy Neilayan Sen and Ross Abrams 8. Stereotactic Body Radiation Therapy as an Emerging Option for Localized Pancreatic Cancer Rachit Kumar, Lauren M. Rosati, and Joseph M. Herman 9. Assessment of Response to Preoperative Therapy Andre L. Mihaljevic and Jorg Kleeff 10. Emerging Systemic and Targeted Therapies Trailokya Pandit and Philip A. Philip Part 4. Surgery 11. Operative Principles in Managing Patients with Borderline Resectable Pancreas Cancer Kaitlyn J. Kelly and Andrew M. Lowy 12. Is There a Role for Laparoscopic and/or Robotic Techniques for Borderline Resectable Tumors? Lee M. Ocuin, Herbert J. Zeh III, and Amer H. Zureikat 13. Role and Techniques Of Vascular Resection Mark J. Truty 14. Artery-First Approaches to Pancreaticoduodenectomy Kyoichi Takaori and Shinji Uemoto 15. Venous Shunting Procedures for Borderline Resectable Pancreatic Cancer Amir H. Fathi, Susan Tsai, Jeffrey E. Lee, Douglas B. Evans, and Kathleen K. Christians 16. The Role of the Appleby Operation and Arterial Resection in the Multimodality Management of Borderline Resectable Pancreatic Cancer Ken-ichi Okada and Hiroki Yamaue 17. Surgery for Borderline Resectable Pancreatic Cancer: The Japanese Experience Shuji Isaji, Masashi Kishiwada, and Hiroyuki Kato 18. The Role of Irreversible Electroporation and Other Ablative Techniques in Patients with Borderline Resectable Pancreatic Cancer Robert C.G. Martin II and Rachel O'Connor 19. Surgical Approach to Borderline Resectable tumors of the Left Pancreas Nicholas Spinelli and William Hawkins 20. Palliative Operations for Unresectable Pancreatic Cancer Hishaam Ismael and Brian Badgwell