The Future of Hiv-1 Therapeutics (Current Topics in Microbiology and Immunology, Vol. 389)

Description

This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.

Table of Contents

HIV Therapy ­ Looking Towards the Future
David Looney, Ariel Ma, and Scott Johns

Computational challenges of structure-based approaches applied to HIV
Stefano Forli and Arthur J. Olson

Nucleocapsid Protein: A Desirable Target For Future Therapies Against HIV-1
Mattia Mori, Lesia Kovalenko, Sébastien Lyonnais, Danny Antaki, Bruce E. Torbett, Maurizio Botta, Gilles Mirambeau, and Yves Mély

HIV-1 integrase multimerization as a therapeutic target
Lei Feng, Ross Larue, Jacques J. Kessl, and Mamuka Kvaratskhelia

Targeting HIV transcription: The quest for a functional cure
Guillaume Mousseau, Sonia Mediouni, and Susana T. Valente

Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder
Stuart F.J. Le Grice

HIV-1 Gag: An Emerging Target for Antiretroviral Therapy
Philip R. Tedbury and Eric O. Freed

The Triple Threat of HIV-1 Protease Inhibitors
Marc Potempa, Sook-Kyung Lee, Richard Wolfenden, and Ronald Swanstrom

Illustrations of the HIV Life Cycle
David S. Goodsell

Index