This book provides comprehensive reviews on our most recent understanding of the molecular and cellular mechanisms underlying atherosclerosis and calcific aortic valve disease (CAVD) as visualized in animal models and patients using optical molecular imaging, PET-CT, ultrasound and MRI. In addition to presenting up-to-date information on the multimodality imaging of specific pro-inflammatory or pro-calcification pathways in atherosclerosis and CAVD, the book addresses the intriguing issue of whether cardiovascular calcification is an inflammatory disease, as has been recently supported by several preclinical and clinical imaging studies. In order to familiarize researchers and clinicians from other specialties with the basic mechanisms involved, chapters on the fundamental pathobiology of atherosclerosis and CAVD are also included. The imaging chapters, written by some of the foremost investigators in the field, are so organized as to reveal the nature of the involved mechanisms as disease progresses.
- Presents the latest insights from modern imaging modalities into the mechanisms underlying atherosclerosis and calcific aortic valve disease
- Casts light on whether cardiovascular calcification is an inflammatory disease
- Written by leading investigators in the field
Part 1: Preclinical imaging of mechanisms of atherosclerosis and its complications.- Pathobiology and basic mechanisms of atherosclerosis.- Ultrasound imaging of endothelial cell activation and damage in atherosclerosis.- Molecular imaging of macrophages.- Optical molecular imaging of inflammation and calcification in atherosclerosis.- Imaging of antigen-presenting cells.- Imaging of oxidation-specific epitopes.- Intravascular molecular imaging.- Imaging of complications of atherosclerosis (platelets aggregation and thrombosis).- Part 2: Imaging insights into mechanisms of calcific aortic valve disease (CAVD) and calcification.- Pathobiology and basic mechanisms of CAVD.- Molecular imaging of aortic valve inflammation and calcification: Preclinical studies.- PET CT imaging of inflammation and calcification in CAVD: Clinical studies.- Ultrasound imaging of CAVD.- Micro-OCT imaging of microcalcification.- Part 3: Clinical imaging of inflammation and calcification.- MR imaging in cardiovascular disease.- Molecular mechanisms of atherosclerosis imaged by MR.- Cardiovascular nuclear imaging.- Preclinical and clinical PET CT imaging of inflammation and calcification.- Clinical feasibility and monitoring of the effects of anti-inflammatory therapy in atherosclerosis.