· Practical guidance on differential diagnosis based on pathology and
· Advice on selection of ancillary techniques (molecular, immunohistochemical and genetic) to establish a definitive diagnosis
· Numerous high-quality color photomicrographs and electron micrographs illustrating the wide variety of pathologic findings
Peripheral nerve analysis is a challenging task for pathologists, given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics. This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosis of the full range of neuropathies with the aid of a wealth of high-quality color photomicrographs and electron micrographs. The pathologist will benefit greatly from the identification of a variety of artifacts and normal structures occasionally encountered in nerve biopsies that need to be distinguished from specific pathologic alterations. This user-friendly, practical text will be an invaluable aid in achieving the most specific diagnosis possible.
Table of contents
Introduction and Clinical Correlation.- Normal Peripheral Nerve Structure.- Basic Pathological Mechanisms.- Vasculitic Neuropathy.- Diabetic neuropathies.- Skin Biopsies.- Metabolic Neuropathies.- Inflammatory and Immune-Mediated Neuropathies.- Neuropathies Associated with Infectious Diseases.- Amyloid neuropathy.- Genetic Neuropathies.- Dysproteinemias.- Toxin-induced neuropathies.- Miscellaneous neuropathies.