The Molecular Pathobiology of Malignant Process and Molecular Diagnostic Testing for Cancer.- Molecular Diagnostic Methods.- Bioinformatics Analysis In Molecular Pathology.- Quality Assurance and Quality Control in Molecular Diagnostic Laboratories.- Breast And Gynecologic Tumors.- Tumors of Central Nervous System.- Lung Cancer.- Gastrointestinal, Hepatobiliary, and Pancreatic Tumors.- Skin Tumors.- Soft Tissue Tumors.- Genitourinary Tumors.- Hereditary Cancer Syndromes and Inherited Cancer Risks.- Acute Myeloid Leukemia.- Myeloproliferative Neoplasms, Myelodysplastic /myeloproliferative Neoplasms and Myelodysplastic Syndromes.- Precursor Lymphoid Neoplasms.- Mature B-Cell Neoplasms.- Plasma Cell Neoplasms.- Mature T- and NK-cell Neoplasms.- Histiocytic and Dendritic Cell Neoplasms.- Bone Marrow Engraftment Analysis.
This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology.
Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.
Yi Ding MD, PhD Department of Laboratory Medicine, Diagnostic Medicine Institute Geisinger Health Danville, PA USA
Linsheng Zhang MD, PhD Department of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta, GA USA