Part I: Differentiated Thyroid Cancer: Initial Management.- 1.A Patient with a Single Thyroid Nodule Suspicious for Follicular Neoplasm According to the Bethesda System for Reporting Thyroid Cytopathology: Molecular Evaluation.- 2.A Young Patient with Intrathyroidal Papillary Thyroid Cancer and Family History of Differentiated Thyroid Cancer.- 3.A Case of a Small (1-2 cm) Papillary Thyroid Cancer in a Young Patient: Lobectomy Versus Total Thyroidectomy.- 4.A Patient with Papillary Microcarcinoma Undergoing Active Surveillance.- 5.Completion Thyroidectomy in a Patient with Low-Risk Papillary Cancer.- 6.A Papillary Thyroid Cancer with Minimal Extra-thyroidal Extension.- 7.A small Papillary Thyroid Cancer with angioinvasion.- 8.A patient with a pathological diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP).- 9.Papillary Thyroid Cancer with Central Neck Lymph Node Metastases.- 10.A Patient with a Large Minimally Invasive Follicular Thyroid Cancer.- 11.A Child with Papillary Thyroid Cancer and Locally Advanced Disease but No Distant Metastasis.- Part II: Differentiated Thyroid Cancer: Postoperative Follow-Up.- 12.A Patient with Papillary Thyroid Cancer and Biochemical Evidence of Disease at the One-Year Follow-Up Visit.- 13.A Patient with Low Risk Papillary Thyroid Cancer Who Has Undergone a Lobectomy: Monitoring for Recurrent Disease and Assessment of Thyroid Function.-14.A Patient with Papillary Thyroid Carcinoma and Biochemical Evidence of Disease at Follow-Up Visits with Increasing Serum Tg Values at the Follow-Up Assessments.- 15.A Young Patient with Recurrent Lymph Node Involvement: Imaging, Cytology, and Thyroglobulin Washout.- Part III: Differentiated Thyroid Cancer: Special Issues.- 16.Papillary Thyroid Carcinoma Diagnosed During Pregnancy.- 17.Risks of Thyroid Hormone Suppression for Differentiated Thyroid Cancer in the Elderly.- 18.A Case with Postsurgical Hypoparathyroidism.- 19.A Patient with Postsurgical Recurrent Laryngeal Nerve Damage and Nerve Monitoring.- Part IV: Differentiated Thyroid Cancer: Managing higher risk patients.- 20.A Case of Papillary Thyroid Cancer Without Aggressive Histological Features with Nodal Metastases Detected During Follow-Up in a Younger Patient.- 21.A Patient with a Large Hurthle Cell Carcinoma of the Thyroid and Nodal Metastases.- 22.A Case of a Large, Invasive PTC with Gross Residual Disease (pT4) After Surgery.- 23.A Patient with Papillary Carcinoma of the Thyroid with Elevated Serum Thyroglobulin but Negative Imaging Studies.- 24.A Young Child with Papillary Thyroid Cancer and Metastatic Pulmonary Disease: Role of Radioactive Iodine Therapy in Children.- 25.A Patient with Bone Metastases from Follicular Carcinoma of the Thyroid.- 26.Radioiodine Therapy in Lactating Women with Higher-Risk Differentiated Thyroid Cancer.- Part V: Differentiated Thyroid Cancer: Beyond Radioactive Iodine Therapy.- 27.A Case of a Patient with Radioactive Iodine Refractory Differentiated Thyroid Cancer with Progressive Neck Disease (Latero-cervical Lymph Nodes) and Stable, Small Lung Metastases.- 28. A Case of a Patient with High Risk Papillary Thyroid Cancer With Gross Residual Disease after Initial Thyroidectomy: Role of External Beam Radiotherapy.- 29.RAI-Refractory Differentiated Thyroid Cancer with Multiple Organ Progressive Disease.- 30.RAI-Refractory Differentiated Thyroid Cancer and Lung Lesions Causing Bleeding.- 31.A Patient with Follicular Thyroid Cancer and a Painful Bone Metastases at Risk for Pathologic Fracture.- 32.Differentiated Thyroid Cancer and Brain Metastases.- 33.RAI-Refractory, Advanced Differentiated Thyroid Cancer Receiving Tyrosine Kinase Inhibitor Treatment: Checking for Drug-Drug Interactions.- Part VI: Medullary Thyroid Cancer.- 34.Management of Postoperative Hypercalcitoninemia in MTC.- 35.A Patient with Metastatic Medullary Thyroid Carcinoma (MTC) and Tumor-Related Diarrhea.- 36.Clinical Management of a Patient with a Locally Recurrent Medullary Thyroid Cancer and Asymptomatic Slowly Progressing Distant Metastases.- 37.A Patient with an Advanced Medullary Thyroid Cancer and Progressive, Symptomatic Distant Metastases: When to Start Systemic Therapy.- 38.Medical Treatment Decision-Making for Advanced, Progressive Medullary Thyroid Cancer.- 39.Screening Leading to Diagnosis of C-Cell Hyperplasia.- 40.Increased Basal Calcitonin in Nodular Goiter: Is It Micromedullary Thyroid Cancer?.- 41.Timing and Extent of Surgery for a Pediatric Patient with Hereditary MTC and Positive Screening for the S891A RET Mutation.- Part VII: Anaplastic Thyroid Cancer.- 42.Anaplastic Thyroid Cancer: Surgery or Not in Locally Advanced Disease.- 43.A Patient with BRAFV600E-mutated Anaplastic Thyroid Cancer with Metastatic Disease
Now in its second edition utilizing brand new clinical case material, this popular, user-friendly text presents the diagnosis and treatment of thyroid cancer and related clinical issues, providing clinicians in endocrinology and oncology with the best real-world strategies to properly manage the various manifestations of thyroid cancer that they may encounter. Each chapter is a case report that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and therapy, as well as the case outcome, literature review, clinical pearls and pitfalls, and bibliography. All recommendations are based on evidence-based clinical practice guidelines and recent literature.
Written by experts in the field, these cases illustrate treatment for both low- and high-risk differentiated thyroid cancer, including surgical approaches, radioiodine therapy, and novel chemotherapies and targeted therapies, as well as postoperative follow-up and special issues. Additional cases demonstrate the management of medullary thyroid cancer and anaplastic thyroid cancer. Topics new to the second edition include information on management of small thyroid cancers with "active surveillance" (without surgery), new chemotherapeutic approaches to advanced thyroid cancer, and new information on a lesion that is no longer considered to be thyroid cancer (Neoplastic Follicular Thyroid Neoplasm with Papillary-Like Features [NIFTP]), as well as material on external beam radiotherapy and new approaches to the management of anaplastic thyroid cancer.
Pragmatic and reader-friendly, this second edition of Thyroid Cancer: A Case-Based Approach will be an excellent resource for clinical endocrinologists and oncologists, endocrine fellows, residents and students alike.
Giorgio Grani, MD, PhD, Assistant Professor of Internal Medicine, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
David S. Cooper, MD, Professor of Medicine and Radiology, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cosimo Durante, MD, Associate Professor of Internal Medicine, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy