Introduction.- Epidemiology and Risk Factors: Epidemiology of Oral Cancer.- Risk Factors for Cancer of the Mouth and Oropharynx.- Human Papillomavirus Infection.- Clinico-Pathological Aspects: Clinical Presentation and Differential Diagnosis of Oral Cancer.- Staging of Oral Cancer.- Pathology of Oral and Oropharyngeal Cancers.- Diagnostic Investigations: Biopsy Techniques.- Adjunctive Techniques.- Detection Techniques and Screening for HPV.- Diagnostic Imaging Techniques.- Natural History: Potentially Malignant Disorders of the Oral Cavity.- Malignant Transformation of Oral Potentially Malignant Disorders.- Molecular and Signalling Pathways during Oral Carcinogenesis.- Early Detection and Prevention: Early Diagnosis of Oral Cancer.- Screening for Oral Cancer.- Life-style Interventions for Oral Cancer Prevention.- Chemoprevention in Oral Cancer.- Management: General Workup Prior to the Treatment Phase of Oral Cancer.- Basic Surgical Principles and Techniques.- Assessment of Surgical Margins.- Chemo-Radiotherapy in Oral Cancer.- De-acceleration of Treatment for HPV Positive Tumours of the Oropharynx.- Treatment of the Neck.- Factors Affecting Survival Following Oral Cancer.- Supportive and Palliative Care for Oral Cancer Patients.- Molecular Targeted Therapies for Advanced Cases of Oral Cancer.- Immunotherapy Based Approaches for Treatment of Oral and Oropharyngeal Cancer.- Outlook and Special Topics in Oral Cancer: Cancer Biology and Carcinogenesis.- Stem Cell Research.- Controversies and Risk Factors of Limited Evidence for Oral Cancer.- Future Application of Molecular Techniques for Diagnosis and Prediction of Prognosis of Oral Cancer.
This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors - all experts in the field of oral oncology - provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.
Saman Warnakulasuriya is Professor Emeritus at King's College London and has been Director of the WHO Collaborating Centre on Oral Cancer since 2005. He is a Past President of the British Dental Association (Metropolitan Branch). Dr. Warnakulasuriya has served on several expert working groups of the International Agency for Research on Cancer (IARC) to evaluate carcinogenicity of substances to humans. He has delivered numerous keynote lectures at international Oral Medicine, Pathology, and Oncology conferences and was on the organizing committee and co-chaired the Global Oral Cancer Forum in New York in 2016. He is a global expert on the epidemiology and risk factors on oral cancer, developed the nomenclature of oral potentially malignant disorders, and has authored more than 250 scientific articles as well as two books, including most recently the Springer book Squamous Cell Carcinoma: Molecular Therapeutic Targets. He is a member of the editorial board of Oral Oncology and Editor-in-Chief of Translational Research on Oral Oncology (Sage Publishing) and also served as Deputy Editor of Oral Diseases from 1995 to 2005. Dr. Warnakulasuriya has received an OBE from Her Majesty the Queen for services to Medicine and in 2015 was awarded the IADR's Distinguished Scientist Award for Oral Medicine & Pathology. He is a Fellow of King's College London.
John S. Greenspan is Distinguished Professor-Emeritus of Oral Pathology in the Department of Orofacial Sciences and Associate Dean-Emeritus for Global Oral Health in the School of Dentistry at University of California, San Francisco (UCSF). He is also Distinguished Professor-Emeritus of Pathology in the School of Medicine and a leading participant in the UCSF Global Health Sciences Program. He is founding Director of the UCSF Oral AIDS Center and of the UCSF AIDS Specimen Bank. Dr. Greenspan is a Past-President of the American Association for Dental Research (AADR) and of the International Association for Dental Research (IADR). He was founding President of the IADR Global Oral Health Inequalities Research Network (IADR-GOHIRN) and founding Director of the International Sjoegren's Syndrome Registry (SICCA). He is a Fellow of King's College London. He has received the American Association for Dental Research (AADR) Distinguished Scientist Award (2010) and the American Dental Association's triennial ADA Gold Medal Award for Dental Research (2012). Dr. Greenspan has made major contributions to global HIV research and care. He has published over 300 papers and four books on oral aspects of AIDS, oral pathology, and immunopathology.