I. Physiological RPE function 1. RPE Histopathology and Morphometry 2. RPE Polarity and Barrier Functions 3. RPE Phagocytosis 4. Ion Channels of the Retinal Pigment Epithelium5. RPE and the Vascular Endothelial Growth Factor 6. The RPE cell and the Immune system
II.The RPE in Disease 7. The RPE in Myopia development 8. Retinal Pigment Epithelium in Proliferative Disorders 9. Retinal pigment epithelium in health and disease: maturation, aging and age-related macular degeneration 10. Retinal Pigment Epithelium in Age-related Macular Degeneration 11. Sex Related Differences in Retinal Pigment Epithelium and Retinal Disease
III. The RPE in Diagnostics 12. RPE in Optical Coherence Tomography13. RPE Autofluorescence IV. The RPE in Therapy 14. RPE and Stem Cell Therapy 15. RPE in Gene Therapy16. RPE and Laser V. Experimental RPE Models 17. RPE Cell Culture18. Retinal Pigment Epithelium Organ Culture19. Animal Models of Diseases of the Retinal Pigment Epithelium
This book provides a contemporary resource on one of the major players in retinal diseases - the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models.
Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.
Professor Alexa Klettner is head of laboratories at the Department of Ophthalmology, University Hospital Kiel and professor of experimental retinology at the Christian Albrecht University, Kiel, Germany.
Professor Stefan Dithmar is Director and Chairman of the Department of Ophthalmology, HSK, Wiesbaden, University of Mainz, Germany.