1. Anatomy and Embryology of the Liver.- 2. Liver Histology.- 3. Hepatic Progenitor Cells.- 4. Hepatocellular Death: Apoptosis, Autophagy, Necrosis and Necroptosis.- 5. Steatosis and inflammation in liver pathology.- 6. Molecular basis of fibrogenesis and angiogenesis during chronic liver disease: Impact of TGF- and VEGF on pathogenic pathways.- 7. Hepatotoxicity: Mechanisms of Liver Injury.- 8. Crosstalk of molecular signaling in hepatocellular carcinoma.- 9. Drug-Induced Liver Injury.- 10. Acquired Metabolic Disorders.- 11. Vascular Disorders of the Liver.- 12. Liver Ischaemia Reperfusion Injury.- 13. Autoimmune Hepatitis.- 14. Primary Sclerosing Cholangitis.- 15. Parasitic Diseases of the Liver.- 16. Viral Hepatitis B.- 17. Viral hepatitis C.- 18. Non-B, Non-C Viral Hepatitis.- 19. The Microbiome in Liver Diseases.- 20. Polycystic Liver Diseases.- 21. Portopulmonary Hypertension and Hepatopulmonary syndrome.- 22. HEPATIC ABSCESSES.- 23. Liver Cirrhosis.- 24. Primary Biliary Cholangitis.- 25. The Paucity of Interlobular Bile Ducts.- 26. Nonalcoholic Fatty Liver Disease: a wide spectrum disease.- 27. Alcoholic Liver Disease.- 28. Liver Disease in Pregnancy.- 29. Cirrhotic Cardiomyopathy.- 30. Benign Tumors.- 31. LIVER CANCER.- 32. Acute Liver Failure.- 33. Chronic Liver Failure and Acute-on-Chronic Liver Failure.- 34. History and Physical Examination.- 35. Assessment of Liver Function.- 36. Noninvasive Biomarkers for liver fibrosis.- 37. Peritoneal Fluid Analysis.- 38. Measurement of Hepatic Venous Pressure Gradient (HVPG).- 39. Liver Biopsy for Histopathology.- 40. Abdominal Ultrasonography.- 41. Endoscopy in Hepatic Diseases.- 42. Dynamic and Multi-phase Contrast-enhanced CT Scan.- 43. Patient-specific 3D printing in Liver Disease.- 44. DYNAMIC CONTRAST-ENHANCED ULTRASONOGRAPHY OF THE LIVER.- 45. Ultrasound Elastography.- 46. MR Elastography and Functional MRI of the Liver.- 47. Dynamic Contrast-enhanced MR Imaging.- 48. Transient elastography in chronic liver diseases.- 49. Portal Venography.- 50. Minilaparoscopy and Conventional Laparoscopy.- 51. MEDICAL NUTRITION THERAPY IN LIVER DISEASE.- 52. Molecular Targets in Liver Disease.- 53. Specific Medications for Chronic Viral Hepatitis.- 54. Portal Vein Embolization (PVE) and Partial Transileocolic PVE with Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy-Beyond the Limitations of PVE.- 55. Endoscopic and Pharmacological Treatment of Esophageal Varices.- 56. Procedure for Gastric Variceal Bleeding - From BRTO to PARTO to CARTO, 3 Decades of Progress.- 57. Endoscopy and endoscopic ultrasound for the evaluation and treatment of gastric and ectopic varices.- 58. Portacaval Shunting for Portal Hypertension.- 59. Systemic Therapy of Advanced Liver Cancer.- 60. Embolization Therapy for Liver Cancer.- 61. Ablation of Hepatocellular Carcinoma.- 62. Laparoscopic Liver Resection.- 63. New locoregional approaches to treat liver cancer.- 64. Hepatic Encephalopathy.- 65. Management of ascites.- 66. Extracorporeal Non Cellular Liver Assisted Devices.- 67. Extracorporeal Cellular Liver Assisted Devices.- 68. Liver Transplantation for Acute and Chronic Liver Failure.- 69. Pre and Post Surgical Complications of Liver Transplantation.- 70. Anesthesia in Liver Transplantation.- 71. Surgery in Liver Disease.- 72. Robotic Liver Surgery.- 73. Cardiac surgery risks in liver dysfunction.- 74. Future Approaches in Liver Disorders: Regenerative Medicine.
This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation.
The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation.
This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.
Reviews and Awards
"This book seeks to reach 'clinicians, practitioners including academics, scientists/researchers, and postgraduates.' ... Readers of this book will achieve a basic understanding of the current status of the field of hepatology. This textbook is a good introduction to the field for general practitioners in medicine and surgery." (Alla Grigorian, Doody's Book Reviews, September 18, 2020)
Florentina Radu-Ionita, MD, PhD is Consultant of Internal Medicine and Gastroenterology, Associated Professor to Gastroenterology Department, Faculty of Medicine, "Titu Maiorescu" University, Bucharest, Romania and from 2014 is the Director of Central Military Emergency University Hospital "Dr. Carol Davila", Bucharest, Romania. Author and co-author of 3 books, 4 chapters in specialty books, over 280 articles and scientific works, published in Romania and abroad in specialty journals or in the brochures of scientific manifestations. Moreover, is co-author of the Patent for invention no. RO 001/2017 "Method for Obtaining Fydroxyapatite Scaffolds with Predetermined Physico-Chemical Characteristics for Major Bone Reconstruction". She is Editor-in-Chief of Romanian Journal of Military Medicine, CNCSIS C, ISSN-L1222-5126; eISSN 2501-2312; pISSN 1222-5126. She is mainly investigator and sub-investigator in over 25 international multicentric clinical studies. Associate Professor Ionita received multiple awards for his work. More important, she is supervisor in specialized training for resident doctors in gastroenterology, having numerous national universitary lectures for students and residents.
Nikolaos T. Pyrsopoulos, MD, PhD, MBA, FACP, AGAF, FAASLD, FRCP (Edin) currently serves as Professor of Medicine and Chief of Gastroenterology & Hepatology at New Jersey Medical School, Professor of Physiology, Pharmacology and Neuroscience and the Medical Director of Liver Transplantation for University Hospital. In addition, he one of the Editors in Chief for the World Journal of Hepatology and of other well-known journals in the field of Hepatology and Gastroenterology. Moreover, he has numerous publications in various scientific journals, including the Journal of Gastroenterology, Hepatology and Transplantation and is one of the authors in the book devoted to the unique field of abdominal transplantation: Intestinal and Multivisceral Transplantation. He has served in numerous national and institutional committees. In addition, he served as the Region 2 Review Board Chair for UNOS and as the Liver and Intestinal committee representative of UNOS region 2. A notorious speaker, Dr. Pyrsopoulos has given national and international talks and lectures on a variety of topics within Hepatology and Gastroenterology. He has served as Activity Director for ten annual national conferences sponsored by Rutgers, Update on Liver Disease and Digestive Disease: New Advances. Furthermore, Dr. Pyrsopoulos has participated in numerous international and national multicenter clinical research projects. He has been elected as the Rutgers NJMS Faculty Organization president. His vision is excellence in patient care, providing outstanding education to the fellows, residents and students and promoting the science of medicine by conducting research.
Mariana Jinga MD, MPH, PhD is Professor of Medicine, Head of Internal Medicine and Gastroenterology Department, Consultant of Internal Medicine and Gastroenterology at "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest; Professor of Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She is member of Editorial Board of Romanian Journal of Military Medicine, and reviewer of many journals. She has participated in more than 280 scientific events and national and international training courses. More than 400 articles and scientific papers published or communicated in the country and abroad, 28 books and chapters in specialized books, in national and international publishing houses, as author, coordinator or co-author. She was principal investigator and co-investigator in 37 international clinical studies and in 13 national clinical studies, researcher in 19 national projects and in 5 international projects (EU's Seventh Framework Programme for Research - FP 7).
Ion C. Tintoiu MD, PhD, FESC is Consultant of Internal Medicine and Cardiology, Professor of Cardiology Faculty of Medicine, "Titu Maiorescu" University of Medicine and Pharmacy, Bucharest and presently Chief of Interventional Cardiology Department, "Carol Davila" Central Military Emergency University Hospital, Bucharest.
Professor Tintoiu received multiple awards and honors for his work, being author and co-author of 12 specialized monographs, 421 journals from multiple medical specialties. He has lectured extensively during his activity, and is a member of Editorial Board of 10 cardiology journals. Moreover, is a member of numerous PhD program committees and member of boards for Consultant examination degree.
Zhonghua Sun MD, PhD is a Professor and discipline lead of medical radiation sciences at Curtin University, Australia. His research interests include diagnostic imaging, 3D medical image visualization and processing, hemodynamic analysis of cardiovascular disease and 3D printing in medicine. He has extensive research experience in cardiovascular imaging with prolific publications in refereed journals. His research outputs include publications of 5 books, 13 book chapters and more than 250 refereed journal article publications. He is involved in many international professional societies including prestigious ones such as American Heart Association (Premium Plus Professional Member), Society of Cardiovascular Computed Tomography (Fellow of SCCT), Asian Society of Cardiovascular Imaging (Member and Auditor of ASCI), Asian Oceania Congress of Medical Physics (AOCMP), International Society of Digital Medicine (Foundation & Council Member). He serves as an academic/associate editor in five journals and editorial board member in more than 30 international journals. Furthermore, he is an invited speaker at many international conferences.
Ecaterina Bontas, MD, MSc is Specialist Physician of Internal Medicine, Specialized in Lyme Chronic Diseases and co-infections, Resident of Cardiology, Cardiology Department "Prof. C.C. Iliescu" Emergency Institute for Cardiovascular Diseases, Bucharest, Romania. In addition, she is Microsoft Certified in Repair PC and Web Designer (HTML, DHTML). Her Master & DIC Certificate of Echocardiography was completed at Imperial College of London. She has received numerous awards and fellowships during her training of Internal Medicine. She published one book as co-author, 14 chapters in specialized Publishing Houses, and 40 articles as author/co-author. In addition, she is member on life of Working Group on Myocardial Function from European Society of Cardiology - WG04/120885/20080314 and member of ILADS (The International Lyme and Associated Diseases Society).