Drawing on years of significant scientific advances and clinical developments, the editors of POMO III have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules. The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a "disease process" involving key regulatory pathways. The second edition (2004) reaffirmed this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics-expression profiling of genes and proteins- with developmental therapeutics, and the "binary state" concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer. Comprehensive and intellectually stimulating, POMO III not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much neglected gap between "information" and "knowledge," and holds out the hope of new anticancer strategies that will reduce the process of carcinogenesis, cancer cell proliferation and significantly reduce metastasis.
Oncologists, hematologists, cancer researchers
Table of contents
Foreward to 1st Edition.- Foreward to 1st Edition.- Foreward to 2nd Edition.- Foreward to 3rd Edition.- Preface.- List Contributors.- 1. Selecting Targets.- 2. Prognostic Factors.- 3. Sporadic Tumor Markers.- 4. Hereditary Tumor Markers.- 5. Circulating Tumor Markers.- 6. Proteonomics.- 7. Microarrays.- 8. Growth Factor Signaling.- 9. Estrogen Receptor Pathways.- 10. Kinases.- 11. Angiogenesis SwtiPathways.- 12. Apoptosis Pathways.- 13. Genetic Instability.- 14. Epigenomics and Cancer.- 15. Immunotherapy.- 16. Aurora Kinase Inhibitors.- 17. Emerging Molecular Therapies.- 18. Suicide Gene Therapy.- 19. Genotypes that Predict Toxicity.- 20. Chemoprevention of Breast Cancer.- Abbreviations.- Trade Names/Generic Names Used.- Index