Hiv and the Brain

About this book

Within the last decade there have been a number of new and important areas of emphasis in HIV care and research, particularly in the context of brain involvement. Without question, clinical and research innovations in the modern era of the HIV pandemic warrant an update on HIV and the brain. Written by a panel of leading experts, HIV and the Brain: New Challenges in the Modern Era offers a clear picture of brain impairment associated with the virus with particular focus on three emerging areas including different genetic strains of the virus throughout the world, interactions between advanced age and HIV, and the impact of HIV on the brain in the context of chronic, long-term treatment with highly active antiretroviral therapy (HAART). HIV and the Brain: New Challenges in the Modern Era provides a comprehensive review of both basic science and clinical implications in these important areas of the disease. The text is of particular relevance to both research scientists and clinicians involved in HIV in the modern era.

Written for: Practicing neurologists, psychiatrists, clinical psychologists, infectious disease specialists, geriatricians and other health care professionals who manage patients with HIV

Keywords:

• AIDS
• Advanced Age
• Brain
• Clade Diversity
• Cognitive Disturbance
• HAART
• HIV
• Neurobehavioral Consequences
• Neurocognitive Disorders
• Neuropathogenesis
• Neuropsychiatric Disturbance

Table of contents

Chapter 1 Neurocognitive changes in HIV: Evolution of Treatment of HIV Infection.
Erna Milunka Kojic, M.D. Charles Carpenter, M.D.

Chapter 2 Global incidence and epidemiology of the AIDS pandemic, distribution of HIV subtypes and epidemiology of Hepatitis C infection among HIV positive individuals.
Karen T. Tashima, M.D., Aadia Rana, M.D.

Chapter 3 New Insights into HIV Neuropathogenesis.
Tory P. Johnson, M.S., Avindra Nath, M.D.

Chapter 4 Neuropathological findings associated with long term HAART treatment.
Ian. C. Anthony, Ph.D., Jeanne E. Bell, M.D.

Chapter 5 Biomarkers of HIV related Central Nervous System Disease.
Bruce James Brew MBBS MD FRACP, Scott L. Letendre MD

Chapter 6 Neuroimaging Among HIV Infected Patients: Current Knowledge and Future Directions
David F. Tate, Ph.D., Jared Conley, B.S., Dominik Meier, Ph.D., Bradford Navia, M.D., Ph.D., Ronald Cohen, Ph.D., Charles R.G. Guttmann, M.D.

Chapter 7 The assessment of HIV-associated neurocognitive disorders: New challenges in the HAART era Chronic neuro-AIDS, long-term cognitive assessment, and new risk factors
Lucette A. Cysique, Ph.D., Bruce J. Brew MBBS MD FRACP

Chapter 8 The changing face of HIV-associated cognitive and neuropsychiatric disturbance.
Ron Cohen, Ph.D.

Chapter 9 Youth with HIV/AIDS: Neurobehavioral Consequences
Susannah Allison, Ph.D., Pamela L. Wolters, Ph.D., Pim Brouwers, Ph.D.

Chapter 10 Co-occurrence of HIV, Hepatitis C, and Substance Use Disorders: Effects on Brain Functioning.
Raul Gonzalez, Ph.D., Phillip J. Quartana, Ph.D., Eileen M. Martin, Ph.D.

Chapter 11 The Functional Impact of HIV-associated Neuropsychological Decline
Matthew J. Wright, Ph.D., Ellen Woo, Ph.D., Terry R. Barclay, Ph.D., & Charles H. Hinkin, Ph.D.

Chapter 12 Adjunctive therapy for long-term support of cognitive impairment
Joshua T. Dearborn, M.A., Susan E. Maloney, M. A., Nicole Hicklin, M.A.
Elizabeth M. Lane, B.A., Robert Paul, Ph.D.

Chapter 13 HIV-1 Genetic diversity and its biological significance.
Michael M. Thomson, M.D., Ph.D.

Chapter 14 Opportunistic infections in the brain in developing countries
Marcus Tulius T Silva, M.D., M.Sc., Ph.D., Beatriz Grinsztejn, M.D., M.Sc., Ph.D.

Chapter 15 Impact of clade diversity on neuropsychological outcomes
Robert Paul, Ph.D., Ned Sacktor, M.D., Lucette Cysique, Ph.D., Bruce Brew, M.D., Victor Valcour, M.D.

Chapter 16 The effects of aging on HIV disease
Robert C. Kalayjian, M.D., Lena Al-Harthi, Ph.D.

Chapter 17 Neuropsychology of Healthy Aging
Molly E. Zimmerman, Ph.D., Adam M. Brickman, Ph.D.

Chapter 18 Interactions between Advanced Age and HIV Cognitive Impairment
Victor Valcour, M.D., Aaron McMurtray , M.D.