In this exciting new volume, the authors draw upon a rich collection of visual material to explore the full range of primary hyperlipidemias. By referring to hundreds of high quality images included in this ground-breaking work, the physician using this book can identify and diagnose the whole spectrum of lipid disorders at the earliest possible stage. In addition, they illustrate how lipid disorders may disrupt other organ systems, sometimes without any symptoms being manifested, and present initially to specialists in fields as diverse as rheumatology, dermatology, orthopaedics or ophthalmology with a further risk of misdiagnosis. A comprehensively illustrated guide to diagnosis, this atlas will assist cardiologists, endocrinologists, primary care physicians and others healthcare professionals in their daily task of making an accurate assessment of the patient and then formulating the most effective management programme for each manifestation of this highly complex group of disorders: illustrates the appearance of commonplace presentations as well as rare and complex disorders; relates observed signs of disease with underlying metabolic disease processes; comprehensive accounts of each condition’s clinical characteristics permit early diagnosis of disease and more effective treatment; reviews key investigative procedures including use of biomarkers, with notes on gene and protein structures including important mutations; extensive references clarify complexities of classification and nomenclature.
1. Hereditary Hypercholesterolemias
A. Dominant monogenic forms – Familial hypercholesterolemia; Familial defective apo-100; Autosomal dominant hypercholesterolemia (FH-3); Deficiency of cholesterol 7a-hydroxylase
B. Recessive Form – Autosomal recessive hypercholesterolemia (ARH); Lysosomal acid lipase deficiency: Wolman’s disease and CESD;
C. Polygenic, sporadic and multifactorial hypercholesterolemias
2. Inherited Hypertriglyceridemias
A. Lipoprotein Lipase (LPL) Deficiency
B. Endogenous hypertriglyceridemia
C. Familial mixed hypertriglyceridemia (type V)
3. Inherited mixed dyslipoproteinemias
A. Familial Combined Hyperlipidemia
B. Familial dysbetalipoproteinemias and remnant excess – Apolipoprotein E deficiency; ApoE mutations, dominant type III and lipoprotein glomerulopathy; Hepatic lipase deficiency; Pseudo type III hyperlipoproteinaemia; Other dyslipidemic conditions associated with ApoE
4. Inherited dyslipoproteinemias of various etiologies
A. Familial Lp(a) hyperlipoproteinemia
B. Familial phytosterolemia
C. Familial hyperalphalipoproteinemia (FHALP) and CETP deficiency
D. Alagille syndrome (AGS) and Progressive Familial Intrahepatic Cholestatsis (PFIC)
BENEFITS: First atlas of its kind, presenting science of lipid disorders in a clinical context. - Provides comprehensive description of clinical presentations permitting early diagnosis of disease. - Ready to-use-information in an easily accessible format for both specialists & general physicians.
READERSHIP: Hospital physicians; Cardiologists, Diabetologists, Endocrinologists and other Specialist Physicians; GPs; Doctors in training
AUTHORS: J Davignon and R Dufour, Clinical Research Institute of Montreal, Montreal, Canada.