About this book
Bone and Cancer is the fifth volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. This title features current knowledge including that on mechanisms of metastasis, the role of the bone microenvironment in cancer progression, how inflammatory cytokines function in metastasis and osteolysis, and the role of osteoblasts, thus bringing to the clinician and researcher cellular and molecular findings that affect the search for drugs, and lead to translational studies.
Each chapter contains an extensive bibliography of benefit to readers who want to learn more about a specific aspect of the chapter topic. Tables, diagrams and figures clarify the skeletal complications in the cellular events that lead to cancer development and progression of disease in bone. Insights stemming from molecular and cellular events to the clinical picture, focus on translation of discoveries in the laboratory to the clinic. Chapters are written by international authorities in the field, giving awareness of the diseases's status, appropriate treatment and potential future research.
The book is of interest to academic clinicians, researchers of bone and bone cancers, professional staff of hospitals and pharmaceutical houses, and personnel involved in, and concerned with, cancer care and therapy.
Other titles in this series:-
- Bone Formation
- Bone Resorption
- Engineering of Functional Skeletal Tissues
- Bone and Osteoarthritis
Academic clinicians, researchers of bone and bone cancers, professional staff of hospitals and pharmaceutical houses, and personnel involved in, and concerned with, cancer care and therapy
Table of contents
Introduction. Primary and Secondary Bone Cancers: A General Overview.- Blood-Bone Axis and Bone Marrow Microenvironment.- Genetics of Osteosarcoma.- Multiple Myeloma and Other Hematological Malignancies of Bone.- Mechanisms of Metastasis to Bone: The Role of Bone Marrow Endothelium.- Lysophosphatidic Acid: Role in Bone and Bone Cancer.- Role of Bone Microenvironment/Metastatic Niche in Cancer Progression.- Detection and Characterization of Disseminated Tumor Cells Present in Bone Marrow of Cancer Patients.- Molecular Imaging of Cancer Cells Growing in Bone.- Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis.- Prostate Cancer Bone Colonization: Osteomimicry in the Bone Niche.- Bone Pain Associated with Cancer Metastasis.- Small Animal Models for the Study of Cancer in Bone.- Hormonal Therapies in Breast and Prostate Cancer: Effects on Bone and the Role of Bisphosphonates.- Therapeutic Approaches to Metastatic Bone Cancer II: Targeted and Non-targeted Systemic Agents.- Role of Allogeneic Bone Marrow Transplant in Cancer Treatment.- Role of Radiosurgery in the Treatment of Bone Localized Cancers.