A decade ago the right heart had been ignored in terms of its functional contribution to the circulation in acquired and congenital heart disease. While it remains a popular characterization, our understanding of right heart hemodynamics and pathophysiology, and their contribution to cardiac disease has matured immensely.
Congenital Diseases in the Right Heart is a timely addition to the literature and represents the state of the art in right heart disease, bringing together experts in the field from across the world. The mandate for each author was to produce a state of the art contribution. Consequently, this book takes the reader from the most recent findings regarding the embryologic origins of the right heart, to the most practical aspects of management of right heart disease in acquired and congenital heart anomalies. Nevertheless, the right heart is not covered to the exclusion of its left-sided counterpart. Indeed, the last ten years have taught us that the right heart cannot be described in isolation. There is virtually no aspect of cardiac anatomy, physiology or disease that is not influenced by biventricular interactions. The understanding and therapeutic modification of such interactions will be a challenge for scientists and clinicians over the next ten years.
This text is a distillation of thought and expertise that will provide the reader with an unique resource in evaluating and managing patients with right heart disease. It will consequently be of great importance to all involved in this discipline, including pediatric cardiologists, cardiac surgeons, intensivists, cardiac pathologists and researchers in anatomy, embryology and cardiology.
Written for: Those interested in congenital and acquired heart disease: cardiologists, cardiac radiologists, cardiothoracic surgeons, and pediatricians
Table of contents
Section 1: Basic Topics.-Embryonic Origins and Molecular Genetics of the Right Heart.-The Morphology of the Right Heart: Relationship to the Left Heart.-Blood Flow Patterns in the Right Heart: Linking Morphology to Physiology.-Right Ventricular Physiology: Heart-Lung and Interventricular Relationships.
Section 2: Pulmonary Vascular Bed.-Pulmonary Endothelial Control of the Pulmonary Microvasculature.-Smooth Muscle and Matrix Responses to Pulmonary Hypertension.-Genetics and Gene Therapy.-Imaging Microvascular Flow.-Functional Imaging of Proximal Pulmonary Arterial and Venous Flows and Hemodynamics.-Transcatheter Intervention on the Central Pulmonary Arteries – Current Techniques and Outcomes.-Surgical Repair of Congenital and Acquired Pulmonary Artery Stenosis.
Section 3: The Systemic Right Ventricle.-Mechanisms of Late Right Ventricular Failure.-Pharmacologic Approaches to the Failing Systemic RV.-Primary and Secondary Physiologic and Anatomic Repairs.
Section 4: Right Ventricular Cardiomyopathies.-Genetic Origins and Clinical Outcomes of Right Ventricular Cardiomyopathies.-The Pathologic Spectrum of Right Ventricular Dysplasias.-Diagnosis of Right Ventricular Cardiomyopathies.-Current Therapies.
Section 5: Acute Right Heart Failure – Perioperative Care.-Imaging the Hypoplastic Right Heart – How Small is Too Small?.-Surgical Decision-Making in the Borderline Right Ventricle.-Postoperative Pulmonary Hypertension: Current Management Strategies.-Ventilatory Management of the Failing Right Heart.-Origins and Treatment of Right Ventricular Dysfunction After Heart Transplantation.
Section 6: Chronic Right Heart Failure.-Non-invasive Assessment of Right Ventricular Contractile Performance.-The Sub-pulmonary Right Ventricle in Chronic Left Ventricular Failure.-Management of the Acutely Right Failing Right Ventricle in Chronic Biventricular Disease.-Late Outcomes of the Fontan Circulation.-Mechanisms of Failure in the Fontan Circulation.
Section 7: Tetralogy of Fallot.-Decision Making in Primary Repair.-Right Ventricular Myocardial with Tetralogy of Fallot: Right Ventricular Myocardial Responses to Chronic Volume and Pressure Load.-Restrictive Right Ventricular Physiology: Early and Late Effects.-Late Arrythmia in Tetralogy of Fallot: Current Approaches to Risk Stratification.-Timing and Outcomes of Surgical Pulmonary Valve Replacement.-Transcatheter Pulmonary Valve Replacement: Role and Limitations.-The Role of Resynchronization Therapy in Right Left Heart Interactions.
Section 8: Ebsteins Anomaly.-Anatomic Definition and Imaging.-Fetal Physiology and Postnatal Outcomes.-The Role of Atrial Shunting and Interventional Closure.-Types and Outcomes of Surgery.