Since the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Significant progress has been accompanied by challenges for scientists, ethicists, and health policy makers. With the recognition of the need for a national system for the collection, banking, distribution, and use of cord blood and the increasing focus on cord blood as an alternative to embryos as a source of tissue for regenerative medicine, it has garnered significant attention recently.
Frontiers in Cord Blood Science contains chapters from distinguished investigators currently engaged in researching cord blood in the treatment of various diseases of the brain, heart, liver, pancreas, bone and cartilage. The current state of research in the field is presented and the potential future applications of cord blood both for research and for the treatment of different diseases and conditions is discussed. In addition, the book reviews the possibility for novel uses in surgical wound healing and in synthetic grafts for reconstructive surgery, allowing their better adhesion.
Investigating the ethical issues, this book will be of interest to all scientists and researchers within the field of regenerative medicine and also clinicians in dermatology, neurology, cardiology and orthopedics wishing to discover more about the potential for the revolutionary medical approach of human umbilical cord blood.
Written for: Gynecologists, hematologists, cell therapists, neurologists, oncologists (including pediatric oncologists), cord blood harvesters, processors and bankersTable of contents
Placenta and Pregnancy Stem Cell.- Cord Blood Stem Cells-The Basic Science.- Ex Vivo Expansion of Cord Blood.- Gene Expression Profiling in Cord Blood and Gene Integration Mapping in Peripheral Blood.- Hematopoietic Stem Cells from Umbilical Cord Blood.- To Characterize Mesenchymal Stromal Cells (MSC) Derived from Cord Blood in Comparison to the Classical Bone Marrow Derived MSC and also with Adipose Tissue Derived MSC.- Cord Blood Mesenchymal Stem Cell.- Double Cord Blood Transplants.- Cord Blood Transplantation for Paediatric Non-Malignant Condition.- Cord Blood Transplantation for Hematologic Malignancies.- Possibilities of Using Cord Blood for Improving the Biocompatibility of Implants.- Use of Cord Blood Stem Cells in the Interphase to Improve the Bio-friendliness of Ceramic Implants.- Transfusion Potentialities of Cord Blood to Combat Anemia of Any Aetiology.- Cord Blood: Opportunities and Challenges for the Reconstructive Surgeon.- Umbilical Cord blood Transfusion – A Clinical Overview.- Cord Blood Use in Ischaemic Stroke.- Cord Blood for Allogeneic and Autologous Banking.- Establishment of the UK Stem Cell Bank and Its Role in Stem Cell Science.- Ethics and Cord Blood.