Providing a reference that is both authoritative and accessible for daily use, key features of this evidence-based, highly acclaimed work include:
more than 2750 major topics covering the vast patient mix primarily treated by adult and pediatric neurologists the most current definitive medical citations section editors who are all internationally recognized leaders in their fields new chapters addressing the important issues of stem cell therapy, pharmacogenomics, palliative care, the management of the organ donor, metabolic myelopathy, superficial siderosis and attention deficit hyperactivity disorder focus on the issues underlying treatment decisions not only for the most readily treated disorders but also for conditions with few existing, definitive therapeutic options comprehensive summary tables and informative figures, with the most recent supporting recommendations to guide treatment decisions for effective and efficient patient management in the busy clinic setting.
Building upon the success of its predecessor, this important second edition continues to address the need for a comprehensive textbook focused primarily on therapeutics, and will help busy students, clinicians and clinician-scientists in understanding the current status of neurological therapeutics in planning the care of their patients.
Table of Contents
Section 1: Principles of Therapeutics.
1. Basic Pharmaceutical Principles and the Blood-Brain Barrier 2. Molecular Therapies for the Nervous System and Muscle 3. Clinical Trial Methodology, FDA Terminology and Procedures 4. Placebo Analgesia 5. Evidence-Based Medicine 6. Ethical Issues in Neurological Treatment and Clinical Trials 7. Domestic Violence in Neurological Practice 7a. Palliative Care and Hospice 7b. Stem Cells
Section 2: Pain: Headache, Spine and Limb Pain.
8. Principles of Pain Management 9. Migraine 10. Cluster Headaches 11. Tension-Type Headache 12. Chronic Daily Headache 13. Post-Traumatic Headache 14. Indomethacin-Responsive Headache Syndromes 15. Giant Cell Arteritis 16. Headache “Syndromes” in Children and Adolescents 17. Diagnosis and Treatment of Common Orofacial Pain Conditions 18. Radicular Limb Pain 19. Back Pain 20. Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy, Cuasalgia, Shoulder-Hand Syndrome) 21. The Treatment of Central Pain 22. Peripheral (Neuropathic) Pain Disorders 23. Cancer Pain 24. Fibromyalgia and Myofascial Pain Syndrome 25. Pain Disorder
Section 3: Seizure Disorders
26. Classification and Epidemiology of Seizure Disorders: Therapeutic Implications and Importance 27. Pathophysiology of the Epilepsies 28. Principles in Epilepsy: Differential Diagnosis and Pharmacotherapy 29. Antiseizure Drugs 30. Surgery and Non-Pharmacological Therapies for Epilepsy 31. Status Epilepticus 32. The Treatment of Epilepsy in Children and Infants 33. Seizures and Epilepsy in Women 34. Imitators of epilepsy 35. Legal and Regulatory Issues for People with Epilepsy
Section 4: Cerebrovascular Disease
37. Principles of Atherosclerosis and Atherogenesis 38. Stroke Prevention 38. Anticoagulant Therapy and Antiplatelet Drugs 39. Thrombolytic Therapy for Stroke 40. Asymptomatic Carotid Artery Stenosis 41. Transient Ischemic Attacks 42. Management of Patients with Acute Ischemic Stroke 43. Cardioembolic Stroke 44. Cerebral Complications after Cardiac Surgery and Cardiac Arrest 45. Hypoxic-Ischemic Encephalopathy 46. Treatment of Intracerebral Hemorrhage 47. Subarachnoid Hemorrhage Due to Cerebral Aneurysms 48. Cerebral Aneurysms and Vascular Malformations 49. Unruptured Intracranial Aneurysms 50. Cervicocephalic Arterial Dissections 51. Fibromuscular Dysplasia 52. Venous Disorders 53. Spinal Cord Vascular Syndromes 54. Disorders of Coagulation 55. Antiphospholipid Antibodies and Variants 56. Hypertensive Encephalopathy 57. Cerebral Autosomal Dominant Arteriopathy with Subcoritical Infarcts and Leukoencephalopathy (CADASIL) 58. Moyamoya Disease 59. Stroke in Children 60. Stroke in Pregnancy 61. Superficial Siderosis
Section 5: Neuro-oncology
62. A Perspective on Neuro-oncology 63. Chemotherapy and Antineoplastic Agents 64. Radiotherapy for CNS Neoplasms: Principles, Technologies and Indications 65. Surgically Curable Brain Tumors of Adults 66. Diagnosis and Treatment of Pituitary Tumors 67. Diffuse Cerebral Gliomas in Adults 68. Malignant Brain Tumors of Childhood 69. Germ Cell Tumors and Primary Central Nervous System Lymphoma 70. Brain Metastases
'It was an undiluted pleasure to read and review this magnificent two-volume textbook ... the text is very well laid out, with clear and very helpful summary tables and algorithms...a lot of thought has clearly gone into the arrangement of the sections and chapters ... [it] more than succeeds in its aim of covering the basics of neurotherapeutics. This is a book with a future, born to fill a hole. I have often asked the questions that this book answers. I have no hesitation in recommending it for the neurologist's bookshelf.' - The Lancet Neurology (of the previous edition)
'It's hard to imagine a better and more useful book on neurological therapeutics. This is a true tour de force. The outcome is a book that is simultaneously beautiful, valuable, and comprehensive in its scope. No neurologist will want to do without this wonderfully executed text of neurological therapeutics. Weighted Numerical Score: 100 - 5 Stars!' - Doody's Review (of the previous edition)
'This is a brilliant book, which I think is a real winner ... What makes the book exceptionally useful is that it addresses many of the ... more peripheral issues that one frequently encounters in the wards, but that are not so often addressed in other texts ... With its clarity of thought about what it is trying to achieve, and its innovative approaches to achieve this, it fills a real niche in the market, and would make a truly deserving winner of the 2004 BMA Book Competition.' - First Prize, Neurology Category, 2004 BMA Medical Book Competition (of the previous edition)
'A superb and remarkably broad up-to-date reference encyclopedia of clinical neurology. The breadth and expertise of the contents for our millennium are worthy of comparison to my single-author 19th century classic, Gowers' Handbook (Manual of Diseases of the Nervous System).' - Archives of Neurology, Volume 62, April 2005 (of the previous edition)