Textbook of Malignant Hematology

The second edition of this successful title has been fully revised and updated and now includes expanded sections on normal and malignant haematopoiesis, offering a thorough review of the molecular and cellular processes involved in malignancy, developments in diagnostic techniques and treatment, concluding with discussion of treatment of individual diseases, late effects of therapy and supportive care.

Contents:

• Part 1: Normal Hematopoiesis
  1. The Stem Cell 2. Stem Cell Plasticity 3. Cytokine Receptors and Signal Transduction 4. Cell Cycle Regulation 5. Transcription Factors in Hematopoietic Differentiation and Lukemia 6. Cellular Aspects of Lymphoid Differentiation: B Cells 7. Cellular Aspects of Lymphoid Differentiation: T and NK Cells 8. Dendritic Cell Development 9. Granulomonopoiesis 10. Erythropoiesis 11. Megakaryocyte Differentiation and Regulation
• Part 2: Mechanisms of Transformation
  12. DNA Repair and Malignant Hematopoesis 13. Senescence and Telomeres 14. Angiogenesis and Tumor Development 15. Lymphoproliferations Associated with Human T-cell Leukaemia/Lymphoma Virus Type I and Type II 16. Immunosuppression: Epstein-Barr Virus and Hemtologic Malignancies
• Part 3: Developments in Diagnosis
  17. Acquired Genetic Changes in Myeloit Malignancies 18. Cytogenetic and Molecular Abnormalities in Lympoid Malignancies 19. Analysis of Clonality Using X-chromosome Inactivation Patterns 20. Microarray Aanalysis and Expression Profiling 21. Detection of Minimal Residual Disease in Lymphoid Malignancies 22. Detection of Minimal Residual Disease in Myeloid Malignancies
• Part 4: Developments in Treatment
  23. Drug Resistance and its Modifications in Hematologic Malignancies 24. The Theoretical Basis of Chemotherapy for Hematological Malignancy 25. Humoral Immunotherapy and the Use of Monoclonal Antibodies 26. T-cell Mediated Immunotherapy of Cancer 27. Interference with Signalling Pathways in Malignant Disease 28. Gene Therapy and Molecular Manipulation 29. Allogeneic Stem Cell Transplantation
• Part 5: Clinical Diseases
  30. Epidemiology 31. Lymphoid Malignancies in Children 32. Acute Lymphoblastic Leukaemia in Adults 33. Chronic Lymphoid Leukemias 34. Multiple Myeloma 35. Hodgkin's Disease 36. Non-Hodgkin's Lymphomas 37. Acute Myeloid Leukemia in Children and Adolescents 38. Acute Myeloid Leukemia in Adults 39. Acute promyelocytic Leukemia 40. Myelodysplastic Syndromes 41. Chronic Myeloid Leukemia 42. Chronic Myeloid Disorders, Excluding CML
• Part 6: Late Effects of Therapy
  43. Late Effects Following Treatment for Hodgkin's Disease 44. Late Effects in Children Treated for Acute Leukaemia 45. Late Effects Following Allogeneic Stem Cell Transplantation
• Part 7: Supportive Care
  46. Hematopoietic Growth Factors 47. Management of Infectious Complications in Hematological Patients