The recently published article “The Burden of Liver Disease in Europe: A Review of Available Epidemiological Data” provides a few figures on the enormous problem that liver disease poses for Europeans. Liver disease is estimated to cause 170,000 deaths annually in Europe, 47,000 of which are attributed to liver cancer; 0.5%-0.7% of the European population is affected by chronic hepatitis B; and prevalence rates of hepatitis C virus (HCV) infection in the last decade in the European population ranged from 0.13 to 3.26%. These HCV-infected populations will develop complications in the years to come. It is of great concern that about 90% of people in Europe infected by viral hepatitis are unaware of their status. Alcoholic and non-alcoholic fatty liver disease (NAFLD) must also be added to the picture. NAFLD is becoming a major concern with the increasing incidence of obesity and type 2 diabetes in Europe. The burden of liver disease is not less pessimistic in North America, Asia and the rest of the world.
Table of Contents
Preface; Hepatic Failure as an Early Complication Following Orthotopic Liver Transplantation; Neurological Complications in Liver Transplantation; Hepatic Encephalopathy, Cerebral Blood Flow & the Changes in Oxidative Metabolism; New Insight into the Molecular Roles in the Pathogenesis of Hepatic Encephalopathy; Disordered Central Neural Regulation of the Cardiovascular System in Liver Failure; Hepatic Microcirculation in Chronic Liver Disease; Astrocytes & Endothelial Cells Behavior Found in Brain Hippocampus in Prehepatic Portal Hypertensive Rats; Direct Antiviral Agents for Chronic Viral Hepatitis Treatment; Emergent Therapies in Acute Liver Failure; Overview of Artificial Liver Support Systems in the World & New Promising Methods; Cell Therapy in Human Liver-Based Diseases; Emerging Therapies for Parenteral Nutrition-Associated Liver Failure in Children: A Focus on Preventative Strategies; The Endocannabinoid System in Hepatic Encephalopathy: Pathophysiology & Therapeutic Potential; The Role of MicroRNA in Liver Failure & Hepatic Carcinogenesis; Index.