Lymphedema is a huge global health problem, with up to 7 million sufferers in the U.S. alone. Lymphedema: Complete Surgical and Medical Management is one of the first books to cover the state of the field, covering both surgical and non-surgical treatment.
The book is divided into four sections that discuss current concepts in lymphedema, diagnosis, treatment, and further directions for research. It begins with chapters on anatomy and embryology, discusses the physiology of the lymphatic system, and examines the pathophysiology of primary and secondary lymphedema. It reviews risk factors in breast cancer, examines lymphedema in paediatrics, and explores sentinel node biopsy. The book also describes psychological and dermatological implications.
Next, the authors discuss diagnosis modalities such as duplex ultrasonography, ICG lymphography, magnetic resonance imaging, and other diagnostic tools. Chapters also explore differential lymph node mapping and clinical staging.
The third section provides a history of lymphedema treatment and an overview of various past and present treatments in India and China. It explores pharmacological options, excisional approaches, liposuction, and venous implantation methods. Lymphatic grafts and surgical treatments are also considered.
The final section discusses current research and possible areas for future inquiry in this area. The authors discusss animal modeling for lymphedema research and molecular approaches to the management of lymphedema. They examine the relationship between fat tissue and lymphangiogenesis, quality of life issues, and future directions for lymphedema management.
The book uses a consistent templated format, is well-illustrated in full color throughout, and includes a DVD with surgical video clips. With U.S., European, and Asian-Pacific contributors, it provides a truly global approach.
- Comprehensive coverage of lymphedema—from diagnosis to treatment to future directions, such as molecular approaches
- Focusses on medical and surgical management
- Includes operative videos with key details of main surgical approaches
- Published in full color with over 500 illustrations
- Includes a bonus eBook version compatible with a wide range of devices
Table of Contents
Current Concepts in Lymphedema
- Lymphedema: Lack of Solutions to a Clinical Problem; Peter Neligan
- Anatomy and Embryology; M. Amore
- Physiology of Lymphatic System – Lymphangiogenesis; Babak Mehrara
- Pathophysiology of Primary Lymphedema; Neil Piller
- Pathophysiology of Secondary Lymphedema; E. Foldi
- Etiology and Classification; Stanley Rockson
- Lymphedema Risk Factors in Breast Cancer; Stanley Rockson
- Filaria; Gurusamy Manoharan
- Lymphedema in Paediatrics; Cristobal Miguel Papendieck
- Lymphatic Malformations; Sandro Michelini
- Venous Failure – Lymphatic Impact; Audra Duncan
- Sentinel Lymph Node Biopsy and Lymphedema; Stanley Leong
- Psychological and Functional Impairment; Jane Armer, Jennifer Hulett, Janice Cormier, Bob Stewart, Ausanee Wanchai, and Kate Cromwell
- Changing Concepts in Lymphatic Pathways; Wei Ren Pan
- Dermatologic Implications of Lymphedema; Terence Ryan
Diagnosis of Lymphedema
- Impact of Genetics on the Development of Lymphatic System; Kristiana Gordon and Sahar Mansour
- Approach to the Diagnosis; Mary Witte
- Bio-Markers; Jörg Wilting and Kerstin Buttler
- Imaging Diagnosis: General Guidelines; Mauro Andrade
- Lymphoscintigraphy; B-B. Lee
- Duplex Ultrasonography
- ICG Lymphography; Mitsunaga Narushima
- Magnetic Resonance Imaging and Other Diagnostic Tools; Lee Mitsumori
- Lymphatic Flow Patterns; Isao Koshima
- Measuring Methods; Peter Neligan
- Differential Lymph Node Mapping; Joseph Dayan
- Lymph Pressure and Flow Measurements; Beatrice Amann-Vesti
- Clinical Staging; Sandro Michelini
Current Treatment of Lymphedema
- History of Surgical Lymphedema Treatment; Leo Clodius
- Surgical Treatment in India (Past and Present); Rajiv Agarwal
- Surgical Treatment in China (Past and Present); N. Liu
- Pharmacological Treatment of Lymphedema; Kathleen Wang
- Conservative Therapy; Neil Piller
- Interventional Timing (What’s Best and When); Jaume Masia and Peter Neligan
- Excisional Approaches; Peter Neligan
- Liposuction; Hakan Brorson
- Venous Implantation Methods; Corradino Campisi
- Lymphatic Grafts; R. Baumeister
- Lymphatico Venular Anastomosis; Isao Koshima
- Vascularized Lymphnode Transfer; Corinne Becker
- Local Flaps and VLNT; Josh Levine
- TMG and VLNT; Sinikka Suominen
- L.Y.M.P.H.A. Concept; Francesco Boccardo
- Combined Surgical Treatment; Jaume Masia
- Lymphedema Complication Treatment; Arin Greene, and Reid Maclellan
Research and Future Directions
- Animal Models for Lymphedema Research; B. Mehrara
- Molecular Approaches to Management of Lymphedema (Stem Cells); A. Saristo
- Relationship between Fat Tissue and Lymphangiogenesis; M. Andrade
- Quality of Life; Vaughan Keeley
- How to Establish a Lymphedema Framework; Christine Moffatt and Agnes Carrott
Peter Neligan, MD is a University of Washington professor of surgery and director of the Center for Reconstructive Surgery at UW Medical Center, as well as an acknowledged expert in the field of reconstructive microsurgery.
Originally from Ireland, he completed his surgical training there before moving to Toronto, Canada in 1983 for further training in microvascular surgery. He developed his interest in reconstructive microsurgery, concentrating on post-oncologic reconstruction.
Dr. Neligan served as chair of the division of plastic surgery at the University of Toronto from 1996 to 2007 and was appointed Wharton Chair in Reconstructive Plastic Surgery at that institution. He was recruited to the University of Washington in 2007 to establish the Center for Reconstructive Surgery.
The scope of his work includes complex reconstructions of all kinds of major defects, as well as microvascular breast reconstruction and head and neck reconstruction. He also has an interest in composite tissue allotransplantation.