Estrogen Prevention for Breast Cancer

Description:

From the early 80s of the past century, clinical and epidemiological studies have increasingly pointed to an elevated breast, endometrial and ovarian cancer risk from high circulating estrogen levels. Estrogen deficiency as a cancer risk factor emerged first in 2007 in a study on Hungarian oral cancer cases based on the gender and age-related differences in tumor prevalence. Critical reevaluation of the contradictory results of hormone replacement therapy yielded a complete conversion that estrogen deficiency may confer cancer initiation. This book examines the deleterious interactions between estrogen deficiency and further hormonal disorders which illuminate the apparently controversial associations of obesity, light exposure and alcohol intake with breast cancer risk. (Imprint: Nova Biomedical)

Contents

Chapter 1 - Discovery of Estrogen Deficiency as Common Cancer Risk Factor for Highly and Moderately Estrogen Dependent Organs (pp. 1-22)
Authors / Editors: (Zsuzsanna Suba, National Institute of Oncology, Department of Surgical and Molecular Pathology, Budapest, Hungary)

Chapter 2 - Interaction between Insulin and Estrogen in the Regulation of Cell Proliferation and Carcinogenesis (pp. 23-42)
Authors / Editors: (Zsuzsanna Suba, National Institute of Oncology, Department of Surgical and Molecular Pathology, Budapest, Hungary)

Chapter 3 - Dose Dependent Biphasic Effect of Alcohol on Estrogen Level and Cancer Risk (pp. 43-58)
Authors / Editors: (Zsuzsanna Suba, National Institute of Oncology, Department of Surgical and Molecular Pathology, Budapest, Hungary)

Chapter 4 - Estrogen Level may be Protective for Breast Cancer in Obese Women (pp. 59-76)
Authors / Editors: (Zsuzsanna Suba, National Institute of Oncology, Department of Surgical and Molecular Pathology, Budapest, Hungary)

Chapter 5 - Newly Recognized Player in Breast Cancer Risk: Light Deficiency (pp. 77-92)
Authors / Editors: (Zsuzsanna Suba, National Institute of Oncology, Department of Surgical and Molecular Pathology, Budapest, Hungary)

Chapter 6 - Estrogen Prevention of Breast Cancer: A Critical Review (pp. 93-104)
Authors / Editors: (Joseph Ragaz, Shayan Shakeraneh, University of British Columbia, B. C., Canada)

Chapter 7 - Chapter 7: Failures and Controversies of the Antiestrogen Treatment of Breast Cancer (pp. 105-126)
Authors / Editors: (Zsuzsanna Suba, National Institute of Oncology, Department of Surgical and Molecular Pathology, Budapest, Hungary)

Chapter 8 - Evolution of Estrogen Action in Breast Cancer: From Culprit to Killer (pp. 127-150)
Authors / Editors: (Mark B. Leick and V. Craig Jordan, Georgetown Lombardi Comprehensive Cancer Center, Washington DC, USA)

Editors: Zsuzsanna Suba (Department of Surgical and Molecular Pathology, National Institute of Oncology, Budapest, Hungary)