Animal Models of Movement Disorders, Vol. I (Neuromethods, Vol. 61)

DESCRIPTION

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems.

Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.

TABLE OF CONTENTS

Part I: Generic Methods of Assessment

• 1. Why Can’t a Rodent Be More like a Man?: A Clinical Perspective
  Anne E. Rosser
• 2. Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders
  Maria Sundvik and Pertti Panula
• 3. Methodological Strategies to Evaluate Functional Effectors Related to Parkinson’s Disease through Application of C. elegans Models
  Kim A. Caldwell and Guy A. Caldwell
• 4. Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson’s Disease
  Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, and Ralph Hillman
• 5. Neurological Evaluation of Movement Disorders in Mice
  Simon Brooks
• 6. Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System
  Jenni M. Karl and Ian Q. Whishaw
• 7. High Throughput Mouse Phenotyping
  Sabine M. Hölter and Lisa Glasl
• 8. MRI of Neurological Damage in Rats and Mice
  Mathias Hoehn
• 9. Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research
  Nadja Van Camp, Yann Bramoullé, and Philippe Hantraye
• 10. Optical Approaches to Studying the Basal Ganglia
  Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress, David L. Wokosin, and D. James Surmeier
• 11. Electrophysiological Analysis of Movement Disorders in Mice
  Shilpa P. Rao, Véronique M. André, Carlos Cepeda, and Michael S. Levine

Part II: Dopamine Systems

• 12. Genetic Models of Parkinson`s Disease
  Ralf Kühn, Daniela Vogt-Weisenhorn, and Wolfgang Wurst
• 13. 6-OHDA Lesion Models of Parkinson’s Disease in the Rat
  Eduardo M. Torres and Stephen B. Dunnett
• 14. 6-OHDA Toxin Model in Mouse
  Gaynor A. Smith and Andreas Heuer
• 15. Rotation in the 6-OHDA Lesioned Rat
  Stephen B. Dunnett and Eduardo M. Torres
• 16. Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson’s Disease Patients Cannot Move Normally
  Gordon W. Arbuthnott
• 17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson’s Disease and Stroke
  Sheila M. Fleming and Timothy Schallert
• 18. Rodent Models of L-DOPA-Induced Dyskinesia
  Hanna S. Lindgren and Emma L. Lane
• 19. Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson’s Disease?
  Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, and Michael W. Jakowec
• 20. The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus)
  Michael J. Jackson and Peter Jenner
• 21. Behavioral Assessment in the African Green Monkey after MPTP Administration
  D. Eugene Redmond, Jr.