In consolidation of the most updated experimental results and perspectives from diverse research fields on a main theme -- Intermittent Hypoxia, this book encompasses the structural, physiological, pathophysiological, biochemical, genetic, metabolic, and therapeutic aspects of intermittent hypoxia and provides an open forum to promote the bench-to-bed translational implications of both adaptive (beneficial) and maladaptive (detrimental) responses to intermittent hypoxia in animals and humans. Authored by 74 leading scientists from 17 countries in Asia, Europe, North America, and Oceana, the 30 chapters are grouped under 7 different sections covering the profound effects of intermittent hypoxia particularly on cardiovascular, respiratory, nervous, and skeletal muscular systems. Special attentions are paid to the protective or injurious roles played by intermittent hypoxia and their underlying cellular and molecular mechanisms in several major human diseases such as acute myocardial infarction, stroke, sleep apnoea, and Parkinson’s disease. Several chapters have also reviewed the use of intermittent hypoxia training for enhancing exercise performance in elite athletes. Overall, as endorsed by Professor John B. West (Member, Institute of Medicine, National Academy of Sciences of USA; Editor-in-Chief, High Altitude Medicine and Biology) through his Foreword for the book, this is the most comprehensive monograph to date on the topic of intermittent hypoxia, which can cause significant structural and functional impact on the systemic, organic, cellular and molecular processes of human physiology and pathophysiology. Hence, this book could serve as a thorough reference for research scientists, physicians, academic faculty, graduate and medical students, athletic coaches and trainers, who are interested in enhancing their knowledge about the past, present, and future of intermittent hypoxia research and its translational applications for prevention and treatment of major diseases and improving exercise performance.
Table of contents
Preface; Foreword; Historical Overview of Intermittent Hypoxia Research; Contrasting Effects of Intermittent Hypoxia on Myocardial Ischemic Tolerance; Effects of Intermittent versus Chronic Hypoxia on Myocardial Ischemic Tolerance; Intermittent Hypoxia-Induced Cardioprotection via iNOS-Dependent Signaling Mechanism; Intermittent Hypoxia-Induced Cardio- & Vasoprotection: Role of NO Stores; Intermittent Hypoxia in Resistance of Cardiac Membrane Structures: Role of Reactive Oxygen Species & Redox Signaling; Beta-Adrenergic Signaling & ROS: Pivotal Roles in Intermittent, Normobaric Hypoxia-Induced Cardioprotection; Role of Protein Kinases in Chronic Intermittent Hypoxia-Induced Cardioprotection; Effects of Intermittent Hypoxia on VEGF Expression & Angiogenesis in Cardiac & Skeletal Muscles; Effects of Sleep-Disordered Breathing on Autonomic; Effects of Intermittent Hypoxia on Pulmonary Arterial Pressure & Right Ventricular Mass; Effects of Intermittent Hypoxia on Ventilatory Response; Intermittent Hypercapnia; Upper Airway Dysfunction Following Chronic Intermittent Hypoxia – Implications for Sleep-Disordered Breathing; Effects of Intermittent Hypoxia on Pulmonary Haemodynamics; Hypoxic Preconditioning Protects Against Oxidative Injury in the Central Nervous System; Effects of Intermittent Hypoxia on Neurogenesis in the Adult & Parkinsonian Rat; Neurotransmitter Synthesis during Intermittent Hypoxia: Role of ROS-Dependent Post-Translational Protein Modifications; The Role of HIF-1 & ROS in Cellular & Systemic Responses to Intermittent Hypoxia; Genetic Selection for Tolerance & Adaptation to Hypoxia; Mitochondrial Signaling in Formation of Body Resistance to Hypoxia; HIF1a, HIF2a, HIF3a & HIF1ß mRNA Expression Changes in Different Tissues under Intermittent Hypoxic Training; Hypoxia & Stem Cells; Effects of Intermittent Hypoxia Training on Peak Performance in Elite Athletes; Use of Intermittent Hypoxia Training in Different Sports; Effects of Intermittent Hypoxia Training on Cytokine Responses to Exercise; Intermittent Hypoxia Exposure & Sleep in Athletes; Effects of Intermittent Hypoxia on Oxygen-Dependent Processes in Skeletal Muscles under Endurance Training; Use of Intermittent Normobaric Hypoxia Trainings in Elderly People; Parkinson’s Disease & Intermittent Hypoxia Training; Equipment & Regimes for Intermittent Hypoxia Therapy; Index.