By suppressing memory and consciousness - two components of the mind - anesthetics provide great relief to surgical patients and elicit wonder in clinicians and scientists. To-date we do not fully understand the mechanisms by which these effects are achieved. However, with recent advances in investigational technologies, ranging from molecular modeling and genetic manipulation to noninvasive functional brain imaging and computational approaches, substantial progress toward this goal has been made during the last decade.
Suppressing the Mind is a multidisciplinary collection of original results and authoritative overviews of the current state of knowledge of the problem written by investigators who are internationally known for their significant contribution to our current understanding of the mechanism of anesthesia. It attempts to bridge molecular, cellular, integrative and systems-level actions of anesthetics with respect to their effects on consciousness and memory. Through a better understanding of how anesthetics work, we hope to also uncover the neurobiological bases of some of the deepest mysteries of the human mind; how it self-reflectively knows, perceives and remembers.
This book should appeal to anesthesiologists, neurologists, psychologists, neuroscientists -- essentially anyone interested in anesthesia, consciousness, or memory. It provides insight into the current state of knowledge, and a perspective for future treatments of the subject as guided by novel hypotheses.
Written for: Anesthesiologists, neurologists, neuroscientists, psychologists, scientists and researchers and anyone else interested in anesthesia or consciousness or memory
Table of contents
Introduction – Anthony G. Hudetz, DBM, PhD and Robert A. Pearce, MD, PhD
- Molecular targets of general anesthetics in the nervous system
Hugh C. Hemmings, Jr., MD, PhD
- A neurochemical perspective on states of consciousness
Christopher J. Watson, PhD, Helen A. Baghdoyan, PhD, and Ralph Lydic, PhD
- Anesthetic modulation of auditory perception: linking cellular, circuit
and behavioral effects
Matthew I. Banks, PhD
- Cortical disintegration mechanism of anesthetic-induced unconsciousness
Anthony G. Hudetz, DBM, PhD
- Anesthesia and the thalamocortical system
Michael T. Alkire, MD
- Anesthesia-induced state transitions in neuronal populations
Jamie Sleigh, MD, Moira Steyn-Ross, MSc, PhD, Alistair Steyn-Ross, MSc, PhD, Logan Voss, PhD, and Marcus Wilson, PhD
- Anesthesia awareness: when the mind is not suppressed
George A. Mashour, MD, PhD
- Loss of recall and the hippocampal circuit effects produced by anesthetics
M. Bruce MacIver, MSc, PhD
- Modulation of the hippocampal theta rhythm as a mechanism for anesthetic-induced
Misha Perouansky, MD and Robert A. Pearce, MD, PhD
- Propofol amnesia- what is going on in the brain?
Robert A. Veselis, MD and Kane O. Pryor, MD