This book covers both classical population genetics theory developed in terms of allele and haplotype frequencies and modern population genetics theory developed in terms of coalescent theory. It features applications of theory to problems that arise in the study of human and other populations and assumes little prior knowledge of mathematics.
1. Allele Frequencies, Genotype Frequencies, and Hardy–Weinberg Equilibrium
2. Genetic Drift and Mutation
3. Coalescence Theory: Relating Theory to Data
4. Population Subdivision
5. Inferring Population History and Demography
6. Linkage Disequilibrium and Gene Mapping
7. Selection I
8. Selection in a Finite Population
9. The Neutral Theory and Tests of Neutrality
10. Selection II: Interaction and Conflict
11. Quantitative Genetics
Appendix A. Basic Probability Theory
Appendix B. The Exponential Distribution and Coalescence Times
Appendix C. Maximum Likelihood and Bayesian Estimation
Appendix D. Critical Values of the Chi-square Distribution with d Degrees of Freedom
Answers to Exercises
Rasmus Nielsen, University of California, Berkeley, USA.
Montgomery Slatkin, University of California, Berkeley, USA.