About this book
Breast Cancer is the most common tumor in women and it is the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammory gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.
Written for:Medical, radiation, and surgical oncologists,
cancer biologists, pathologists
- Breast Cancer
- Breast Cancer therapy
- Gene Expression
- Genomic Basis
- Mammory Glands
- TGF-B Signaling
1.The genomic basis of breast development and differentiation
Jose Russo, MD, and Irma H. Russo, MD, FCAP
2. Mammary Glands, Stem Cells and Breast Cancer
David L. Mack, Ph.D., Gilbert H. Smith, Ph.D. and Brian W. Booth, Ph.D.
3. The genetics of breast cancer: application in clinical practice
Antonio Russo, MD, Valentina Agnese, PhD, Sergio Rizzo, MD, Laura La Paglia, PhD, and Viviana Bazan, PhD
4. Alterations in cell cycle regulatory genes in breast cancer
Annalisa Roberti, PhD, Marcella Macaluso, PhD and Antonio Giordano MD, PhD
5. Neuregulins in the nucleus
Carol M. McClelland, PhD, and William J. Gullick, PhD
6. Role of the EGF-CFC family in mammary gland development and neoplasia
Luigi Strizzi M.D., Ph.D., Kazuhide Watanabe M.D., Ph.D., Mario Mancino Ph.D., David S. Salomon Ph.D. and Caterina Bianco M.D., Ph.D.
7. Modeling human breast cancer: the use of transgenic mice
Rachelle L. Dillon, Ph.D., and William J. Muller, Ph.D.
8. Gene expression profiling in breast cancer: clinical applications
Giuseppe Russo, Ph.D. and Antonio Giordano, M.D., Ph.D.
9. TGF-B signaling: a novel target for treatment of breast cancer?
Jason D. Lee, B.S. and Gerard C. Blobe, M.D., Ph.D.
10. DNA methylation in breast cancer
Moshe Szyf, Ph.D
11. Signal transduction inhibitors in the treatment of breast cancer
Monica R. Maiello, Ph.D., Antonella De Luca Ph.D., Marianna Gallo Ph.D., Amelia D’Alessio Ph.D., Pietro Carotenuto Ph.D. and Nicola Normanno M.D.
12. Integration of target based agents in current protocols of breast cancer
Maria Carmela Piccirillo, MD, Fabiano Falasconi, MSc, Antonia Del Giudice, BS, Gianfranco De Feo, PhD, Jane Bryce, MSN, Mario Iaccarino, PhD, Francesco Perrone, MD, PhD, and Alessandro Morabito, MD.