Cushing's Syndrome. Pathophysiology, Diagnosis and Treatment (Contemporary Endocrinology)

About this book

As a reversible cause of obesity, Cushing’s syndrome is increasingly considered in the differential diagnosis of obese patients. This volume will review the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as menstrual irregularity and depression. It will provide all the up to date information on various strategies to establish the diagnosis of Cushing’s syndrome. Additionally, conditions that represent challenges for the diagnosis, such as renal failure, pediatric age, cyclic hypercortisolism and pregnancy, will be considered. Cushing’s syndrome is caused by a variety of conditions, and its treatment differs according to the etiology. Approaches to the differential diagnosis and specific treatments for each condition will be provided. Chapters that discuss controversies in diagnosis and differential diagnosis will provide a nuanced perspective of these areas.

Written for:

Endocrinologists, general internists, oncologists, pediatricians, gynecologists, neurosurgeons, urologists, endocrine surgeons

Table of contents

• Physiology and Pathophysiology of the HPA axis
  Ayrton Custodio Moreira and Margareth Castro
  University of Sao Paulo at Ribeirao Preto, SP, Brazil
• Etiologies of Cushing´s syndrome
  John Newell-Price
  University of Sheffield, UK
• Pathogenesis of corticotropic tumors
  Shlomo Melmed
  Cedars-Sinai Medical Center, UCLA, Los Angeles, USA
• Pathogenesis of adrenocortical tumors –
  Ana Claudia Latronico, Antonio Lerario and Emilia Modolo Pinto
  University of São Paulo Medical School, São Paulo, SP, Brazil
• Clinical features of Cushing´s syndrome
  Oscar Bruno
  University of Buenos Aires, Argentina
• Laboratorial diagnosis of Cushing´s Syndrome: Differential diagnosis with pseudo-Cushing´s conditions as obesity, alcoholism and depression
  Francesco Cavagnini
  University of Milan, Italy
• Laboratorial diagnosis of Cushing´s syndrome: Differential diagnosis among the different causes of ACTH-dependent and ACTH-independent Cushing´s syndrome
  Luiz R. Salgado and Marcello D.Bronstein
  University of São Paulo Medical School, São Paulo, SP, Brazil
• Imaging for the differential diagnosis of Cushing´s syndrome: MRI, CT and isotopic scanning
  Wouter de Herder – University of Rotherdam, The Netherlands
• Inferior petrosal sampling for the differential diagnosis of ACTH-dependent Cushing´s syndrome
  Findling JW Endocrine-Diabetes Center, , Milwaukee, USA.
• ACTH-dependent Cushing syndrome: Treatment of Cushing´s disease
  Surgical Treatment :
  - Directed to the pituitary :Edward Laws:
  - Directed to the adrenals : William Young:– Mayo Clinic
• Radiotherapy: Mary Lee Vance: Charlottesville, USA
  Medical Therapy: Lynnette K Nieman, National, NIH, Bethesda,USA.
• ACTH-dependent Cushing syndrome : Clinical and diagnostic aspects, and treatment approaches for ectopic Cushing´s syndrome
  Ashley Grossman, St Bartholomew´s Hosp.London
• Nelson´s syndrome
  Xavier Bertagna, University of Paris, France
• ACTH-independent Cushing´s syndrome: Adrenal adenoma and adenocarcinoma
  Maria Candida Fragoso, Ana Cláudia Latronico, Berenice B. Mendonca
• ACTH-independent Cushing´s syndrome: Bilateral macronodular hyperplasia
  Andrew Lacroix – University of Montreal
• ACTH-independent Cushing´s syndrome: primary pigmented nodular adrenal disease in the context of Carney´s complex
  Constantine A Stratakis – NIH, Bethesda, USA
• Glucocorticoid Resistance
  Steven W.Lamberts – University of Rotherdam- The Netherlands
• Post-operative replacement and assessment of HPA axis recovery
  John Wass, Radcliffe Infirmary, Oxford, UK
• Special aspects of Cushing´s syndrome: Pregnancy
  David Aron – Louis Stokes Cleveland Dept of Veterans Affairs Medical Center, Cleveland, OH, USA
• Special aspects of Cushing´s syndrome- Childhood
  M O. Savage -Department of Endocrinology, St Bartholomew's Hosp, London, UK
• Special aspects of Cushing´s syndrome – Cyclic Cushing´s syndrome
  Franco Mantero - Division of Endocrinology, School of Medicine, University of Padua, Padua, Italy