Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.
Preface; Chromatographic Analyses of Biogenic Melatonin and Its Related Indoleamines; 5-Methoxylated Kynuramines: Biologically Active Melatonin Metabolites and Sources of New Products; Advances on the Development of Subtype Selective Melatonin Ligands; The interaction between melatonin and calmodulin: a NMR and molecular dynamics study; The low affinity binding of melatonin to calmodulin: use of computational methods to explain its physiological relevance; Neural regulation of melatonin synthesis; Regulation of melatonin Synthesis: Animal versus Human Studies; Toward a chronome (time structure) of melatonin; Chronobiological aspects of melatonin activity; The molecular basis to the circadian effects of melatonin; Melatonin effects on uterine physiology; Melatonin and Human Reproduction: Why the effect is so elusive?; Melatonin: Immunomodulatory Signal; Photoperiodic vs. non-photoperiodic animals Chr(45) circadian and seasonal changes in immunity; Melatonin: an endogenous antiestrogen with oncostatic properties; Melatonin and Cancer: Basic Research; Melatonin in retinal pathophysiology; The physiology, pharmacology, and anatomical distribution of melatonin receptors in visual system nuclei in the vertebrate CNS; Antioxidant capacity of the neurohormone melatonin; Protective role of melatonin against mitochondrial damage in inflammation; Protective effects of melatonin against hyperhomocysteinemia; Photo- and radiation induced reactions of melatonin by laser photolysis and pulse radioloysis; Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain; Melatonin Receptors in Neuroendocrine Development; The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomised and irradiated rats; The control of Melatonin release from mammalian and avian pineal glands; Effects of chronic melatonin administration on various physiological parameters from old wistar rats; Pineal region tumours; Melatonin and Cancer: therapeutic perspectives; Therapeutic perspectives of gastrointestinal melatonin; Endogenous Versus Exogenous Effects of Melatonin;; Melatonin Circadian Rhythms in Women with Depression: Relationship to the Reproductive Cycle; Melatonin therapy of circadian rhythm sleep disorders in neurodevelopmentally disordered children: a neurological viewpoint; Treatment by melatonin of a genetic disorder: Smith-Magenis syndrome; Melatonin and sleep in shift-workers; Role of Melatonin in the regulation of human circadian rhythms and sleep; Ramelteon, a selective MT1/MT2 receptor agonist, provides a novel treatment for insomnia; Melatonin, Dopamine and Circadian Rhythm in the Restless Legs Syndrome; Sleep and Circadian Neuroendocrine Dysregulation in Seasonal Affective Disorder; Involvement of free radicals and reactive oxygen species in physiological and pathological processes in the thyroid gland; a potential role of melatonin; Role of melatonin in Headache disorders; Ambient illumination and melatonin in the natural setting; Melatonin: effects on smooth muscle and clinical utility; Melatonin and woman; Effects of Melatonin on Cardiovascular System; Melatonin and cerebrovascular disease; Melatonin in Focal Cerebral Ischaemia: Evidence for efficacy and priorities for future research; Understanding the role of melatonin in epilepsy: from bench to bedside; Role of Melatonin on Alzheimer's disease; Longitudinal measurements of melatonin secretion in the elderly: Implications for Alzheimer's Disease; Interactions of Melatonin With Environmental Factors.