Neuroimmunomodulation: From Fundamental Biology to Therapy

Description

This volume highlights the proceedings of the 7th International Congress of the International Society for Neuroimmunomodulation.
The volume provides an overview current research in neural and endocrine mechanisms of immune regulation as well as the effects of peripheral and central immune responses on brain function. Of particular interest are the mechanisms by which local and systemic inflammation act upon the brain, and in turn, how the brain regulates inflammation via direct innervation and release of humoral factors.

Table of Contents

Preface
International Society for Neuroimmunomodulation Award Lecture:

1. Growth hormone modulates migration of developing T cells: Mireille Dardenne, Salete Smaniotto, Valéria de Mello-Coelho, Déa Maria Serra Villa-Verde, and Wilson Savino

Part I: Molecular Basis of Connecting Pathways in Neuroimmunomodulation:

2. Intracellular molecular signaling provides specificity to Glucocorticoids anti-inflammatory actions: Ana C. Liberman, Jimena Druker, Fernando Aprile Garcia, Florian Holsboer, Eduardo Arzt

3. Organizing the thymus gland: The role of Eph and ephrins: Juan José Muñoz, Javier García-Ceca, David Alfaro, Marco Augusto Stimamiglio, Teresa Cejalvo, Eva Jiménez, and Agustín Gregorio Zapata

4. Neuropilins, semaphorins and their role in thymocyte development:

Daniella Arêas Mendes-da-Cruz, Yves Lepelletier, Anne C. Brignier, Salete Smaniotto, Amédée Renand, Pierre Milpied, Mireille Dardenne, Olivier Hermine, and Wilson Savino

5. Leptin action in the thymus: Lício A. Velloso, Wilson Savino, and Eli Mansour

6. Nitric Oxide at the cross-road of immunoneuroendocrine interactions: Valeria Rettori, Javier Fernandez-Solari, Claudia Mohn, María A Zorrilla Zubilete, Carolina de la Cal, Juan Pablo Prestifilippo, Andrea De Laurentiis

Part II: Cytokines/Chemokines Regulating Nervous/Endocrine Tissues:

7. Cytokine control of adult neural stem cells: chronic versus acute exposure: Sylvian Bauer

8. Neuronal cell survival: The role of interleukins: Elizabeth Giestal de Araujo, Gustavo Mataruna da Silva, Aline Araujo dos Santos

9. Interleukin-4 as a Neuromodulatory Cytokine: Roles and Signaling in the Nervous System: Alfred Sholl-Franco, Ana Gabriela Ledo Santos da Silva, Juliana Adão-Novaes.

10. Cytokine-induced suppression of medial preoptic neurons: its mechanisms and neuroimmunomodulatory effects: Toshihiko Katafuchi, Shumin Duan, Sachiko Take and Megumu Yoshimura

11. IL-1 and insulin elicit different neuro-endocrine responses to hypoglycemia: Kazuki Ota, Johannes Wildmann, Taeko Ota, Hugo O. Besedovsky, and Adriana del Rey

12. Intrapituitary Expresion and Regulation of the gp130 Cytokine Interleukin-6 and Its Implication in Pituitary Physiology and Pathophysiology: Ulrich Renner, Eliane Correa De Santana, Juan Gerez, Bianca Fröhlich, Mariana Haedo, Marcelo Paez Pereda, Chiara Onofri, Günter K. Stalla, and Eduardo Arzt

13. The Thymus-Neuroendocrine Axis: Physiology, Molecular Biology and Therapeutic Potential of the Thymic Peptide Thymulin: Paula C. Reggiani, Gustavo R. Morel, Gloria M. Cónsole, Claudio G. Barbeito, Silvia S. Rodriguez, Oscar A. Brown, Maria Jose Bellini, Jean-Marie Pléau, Mireille Dardenne, Rodolfo G. Goya

Part III: Behavioral Effects on Neuroimmunomodulation:

14. Behavior: A Relevant Tool for Brain-Immune Interaction Studies: Frederico Azevedo Costa-Pinto, Daniel Wagner Hamada Cohn, Vanessa Moura Sa-Rocha, Luiz Carlos Sa-Rocha, Joao Palermo-Neto

15. Immunology, signal transduction and behavior in HPA axis-related genetic mouse models: Susana Silberstein, Annette M. Vogl, Juán José Bonfiglio, Wolfgang Wurst, Florian Holsboer, Eduardo Arzt, Jan M. Deussing, and Damián Refojo

16. Behavior and stress reactivity in mouse strains with mitochondrial DNA variations: Ulrike Gimsa, Ellen Kanitz, Winfried Otten, Saleh M. Ibrahim

Part IV: Stress, Inflammation, and Disease:

17. The role of stress factors during aging of the immune system: Moisés E. Bauer, Cristina M. Moriguchi Jeckel, and Clarice Luz

18. Modulation of the Immune System by Ouabain: Sandra Rodrigues-Mascarenhas, Andreia Da Silva De Oliveira, Nívea Dias Amoedo, Ottilia R. Affonso-Mitidieri, Franklin D. Rumjanek, Vivian M. Rumjanek

19. Nutrition, Inflammation and Cognitive Function: Julia Wärnberg, Javier Romeo, Sonia Gomez-Martinez, Ligia-Esperanza Díaz, Ascensión Marcos

20. Early maternal deprivation in rats: A proposed animal model for the study of developmental neuro-immuno-endocrine interactions: M. De la Fuente, R. LLorente, I. Baeza, N.M.De Castro, L. Arranz, J. Cruces, M.P. Viveros

21. Leptin and the immune response: an active player or an innocent bystander?: Anna Carla Goldberg, Freddy Goldberg-Eliaschewitz, Mari Cleide Sogayar, Julieta Genre, and Luiz Vicente Rizzo

22. The Immune-Pineal Axis: Stress as a modulator of pineal gland function: Renato Couto-Moraes, João Palermo-Neto, Regina Pekelmann Markus

23. Neuronal Plasticity and Antidepressants in the Diabetic Brain: Juan Beauquis, Paulina Roig, Alejandro F. De Nicola, and Flavia Saravia

24. Neuroimmune interactions in a model of multiple sclerosis: C. Jane Welsh, Andrew J. Steelman, Wentao Mi, Colin R. Young, Ralph Storts, Thomas H. Welsh, Jr., and Mary W. Meagher

25. Neuroimmune Regulation in Immunocompetence, Acute Illness, and Healing: Istvan Berczi, Andres Quintanar-Stephano, and Kalman Kovacs

26. The Role of Neuroimmunomodulation in Alzheimer’s Disease: Ricardo B. Maccioni, Leonel E. Rojo, Jorge A. Fernández, and Rodrigo O. Kuljis

27. The adrenal steroid response during tuberculosis and its effects on the mycobacterial-driven IFN- production of patients and their household contacts: Veronica Bozza, Luciano D´Attilio, Griselda Didoli, Natalia Santucci, Luis Nannini, Cristina Bogue, Adriana Del Rey, Hugo Besedovsky, Maria Luisa Bay and Oscar Bottasso

28. The chemokine CCL5 is essential for leukocyte recruitment in a model of severe herpes simplex encephalitis: Márcia Carvalho Vilela, Daniel Santos Mansur, Norinne Lacerda-Queiroz, David Henrique Rodrigues, Graciela Kunrath Lima, Rosa Maria Esteves Arantes, Erna Geessien Kroon, Marco Antônio da Silva Campos, Mauro Martins Teixeira, Antônio Lúcio Teixeira.

29. Neuro-endocrine-immunology of experimental Chagas' Disease: Eduardo Roggero, Ana R. Pérez, Oscar A. Bottasso, Hugo O. Besedovsky, and Adriana del Rey

Index of Contributors