Mitochondria and Oxidative Stress in Neurodegenerative Disorders

Description

Our understanding of the interaction of mitochondria with other cellular organelles, with transcription, and in the ability to detect oxidative modification of macromolecules has improved significantly in the past decade. Moreover, the roles of mitochondria and oxidative stress are better defined in the pathophysiology of neurodegenerative disorders. The volume combines basic, clinical, and translational research in a forum designed to provide the most current information on aspects of mitochondrial function and its relationship to age-related neurodegenerative diseases and their treatment.

Table of Contents

Preface: Gary E. Gibson, Rajiv R. Ratan, and M. Flint Beal.

Part I: Mitochondrial Genetics and Neurodegenerative Diseases:.

1. A Mitochondrial Etiology of Neurodegenerative Diseases: Evidence from Parkinson Disease: Elza Khusnutdinova, Irina Gilyazova, Eduardo Ruiz-Pesini, Olga Derbeneva, Rita Khusainova, Irina Khidiyatova, Rim Magzhanov, Douglas C. Wallace.

2. Mitochondrial DNA Mutations in Disease, Aging and Neurodegeneration: Amy K. Reeve, Kim J. Krishnan, Doug Turnbull.

3. What Have PINK1 and HtrA2 Genes Told Us About the Role of Mitochondria in Parkinson's Disease?: Helene Plun-Favreau, Sonia Gandhi , Alison Wood-Kaczmar , Emma Deas, Zhi Yao and Nicholas W Wood.

Part II: Oxidant Actions and Production in Cells:.

4. The Role of Mitochondria in ROS Metabolism and Signaling: Anatoly A. Starkov.

5. Oxidative Stress and Energy Crises in Neuronal Dysfunction: David G. Nicholls.

6. The Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative Stress in Neurodegeneration: Jeffrey A. Johnson, Delinda A. Johnson, Andrew Kraft, Marcus Calkins, Rebekah Jakel, and Marcelo Vargas.

Part III: Evidence for Oxidant Damage in Brains:.

7. Evidence of Oxidative Stress in Alzheimer’s Disease Brain and Anti-Oxidant Therapy: Lights and Shadows: Domenico Praticò.

8. Evidence of Oxidant Damage in Huntington’s Disease: Translational Strategies Using Antioxidants: Edward C. Stack, Wayne R. Matson, and Robert J. Ferrante.

9. Oxidative Stress in Parkinson Disease: A mechanism of pathogenic and therapeutic significance: Chun Zhou, Yong Huang, and Serge Przedborski.

Part IV: Antioxidant Treatments:.

10. Mitochondria-Targeted Antioxidants in the Treatment of Disease: Robin A. J. Smith, Victoria J. Adlam, Frances H. Blaikie, Abdul-Rahman B. Manas, Carolyn M. Porteous, Andrew M. James, Meredith F. Ross, Angela Logan, Helena M. Cochemé, Jan Trnka , Tracy A. Prime , Irina Abakumova, Bruce A. Jones, Aleksandra Filipovska, and Michael P. Murphy.

11. Development of Mitochondria-Targeted Aromatic-Cationic Peptides for Neurodegenerative Diseases: Hazel H. Szeto.

12. A New Approach to Treating Alzheimer’s Disease: John Blass.

Part V: Mitochondria in Different Cell Types:.

13. Postischemic Oxidative Stress Promotes Mitochondrial Metabolic Failure in Neurons and Astrocytes: Gary Fiskum, Camelia A. Danilov, Zara Mehrabian, Linda L. Bambrick, Tibor Kristian, Mary C. McKenna, Irene Hopkins, E.M. Richards, and Robert E. Rosenthal.

14. Imaging Brain Activation: Simple Pictures of Complex Biology: Gerald A. Dienel and Nancy F. Cruz.

15. Structural Diversity of Mitochondria: Functional Implications: Carmen A. Mannella.

Part VI: Mitochondrial Function in Neurodegenerative Diseases:.

16. Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer’s Disease: Lisa Mosconi, Alberto Pupi, Mony J. De Leon.

17. Complexity and Heterogeneity: What Drives The Ever-Changing Brain in Huntington's Disease?: Rosas.

18. Multinuclear Magnetic Resonance Spectroscopy for In Vivo Assessment of Mitochondrial Dysfunction in Parkinson’s Disease: Henchcliffe.

19. Oxidant Induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer’s Disease: H. Diana Rosas, David H Salat, Stephanie Y Lee, Alexandra K Zaleta, Nathanael Hevelone, Steven M. Hersch.

Part VII: Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol:.

20. Mitochondrial and Nuclear Cross Talk in Cell Death: Parthanatos: Shaida A. Andrabi, Ted M. Dawson, and Valina L. Dawson.

21. Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis: Albert Neutzner, Givanni Benard, Richard J Youle, Mariusz Karbowski.

22. Developmental Restructuring of the Creatine Kinase System Integrates Mitochondrial Energetics with Stem Cell Cardiogenesis: Susan Chung, Petras P. Dzeja, Randolph S. Faustino, and Andre Terzic.

23. The Mitochondrial Antioxidants MitoE2 and MitoQ10 Increase Mitochondrial Ca2+ Load Upon Cell Stimulation by Inhibiting Ca2+ Efflux from the Organelle: Sara Leo, György Szabadkai, and Rosario Rizzuto.

24. Preventing NAD+ Depletion Protects Neurons Against Excitotoxicity: Bioenergetic Effects of Mild Mitochondrial Uncoupling and Caloric Restriction: Dong Liu, Michael Pitta, and Mark P. Mattson.

Part VIII: Changes in Mitochondria Important for Neurodegenerative Processes:.

25. Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration: Andrew B. Knott and Ella Bossy-Wetzel.

26. The Disulfide Relay of the Intermembrane Space of Mitochondria: An Oxygen-Sensing System?: Karl Bihlmaier, Nikola Mesecke, Christine Kloeppel, Johannes M. Herrmann.

27. Dysfunction of Mitochondria and Sarcoplasmic Reticulum in the Pathogenesis of Collagen VI Muscular Dystrophies: Paolo Bernardi and Paolo Bonaldo.

Part IX: Mitochondrial Effects on Genes and Gene Expression:.

28. The Mitochondria and the Hypoxia Induced Gene Expression Mediated by the Hypoxia Inducible Factors: Chavez.

29. Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator: Richard C. Scarpulla.

Part X: Gene Array and Proteomic Studies:.

30. Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer’s Disease-Type Amyloid Neuropathology and Spatial Memory Deterioration: Weiping Qin, Wei Zhao, Lap Ho, Jun Wang, Kenneth Walsh, Sam Gandy, and Giulio Maria Pasinetti.

31. Screening for the Metabolic Basis of Neurodegeneration: Developing a Focused Proteomic Approach: James Murray and Roderick A. Capaldi.

Part XI: Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches:.

32. Mitochondria and Huntington's Disease Pathogenesis: Insight from Genetic and Chemical Models: Susan E. Browne.

33. Small Molecule Activation of Adaptive Gene Expression: Tilorone or its Analogs are Novel, Potent Activators of Hypoxia Inducible Factor-1 That Provide Prophylaxis Against Stroke and Spinal Cord Injury: Rajiv R. Ratan, Ambreena Siddiq,, Leila Aminova, Brett Langley, Stephen McConoughey, Ksenia Karpisheva, Hsin-Hwa Lee, Thomas Carmichael, Harley Kornblum, Giovanni Coppola, Daniel H. Geschwind, Ahmet Hoke, Natalya Smirnova, Cameron Rink,Sashwati Roy,Chandan Sen, Michael S. Beattie, Ron P. Hart, Martin Grumet, Dongming Sun, Robert S. Freeman, Gregg L. Semenza, and Irina Gazaryan.

34. Mitochondrial Approaches for Neuroprotection: Rajnish K. Chaturvedi and M. Flint Beal