- Chapter 1. Targeted Therapy in Pediatric Brain Tumors
(Stephanie A. Toll, DO, Jonathan D. Schwartz, DO, Sumit Gupta, MD, and Soumen Khatua, MD, Department of Hematology-Oncology, Children’s Hospital of Michigan, Detroit, Michigan, US, and others)
- Chapter 2. Targeting Energy as a New Strategy to Destroy Cancer Cells
(Bee Ling Tan, Snur M. A. Hassan, Ayman El-Meghawry El-kenawy, Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, and others)
- Chapter 3. Intracellular Mechanisms Involved in Mediating y-Tocotrienol Reversal of Epithelial-to Mesenchymal Transition (EMT) in Breast Cancer Cells
(Paul W. Sylvester, Tasminara Sultana, Nayef Aldabaan, Md. Rafi Anwar and Jessie J. Grazier, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, US)
- Chapter 4. Antimelanogenic Effects of Kojic Acid Derivatives
(Mutlu Aytemir, Gülşah Karakaya and Canan Sevimli Gür, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Hacettepe University, Ankara, Turkey, and others)
- Chapter 5. The Therapeutic Potential of Metformin for Melanoma
(María Florencia Arbe, Franco Alberto Portillo, Gerardo Claudio Glikin, PhD, Liliana María Elena Finocchiaro, PhD, and Marcela Solange Villaverde, PhD, Unidad de Transferencia Genética, Área Investigación, Instituto de Oncología Ángel H. Roffo, Buenos Aires, Argentina, and others)
- Chapter 6. Physical Activity, Exercise as Protective Therapies for Chemotherapy-Induced Cardiotoxicity
(Gabriela Gutiérrez-Salmeán and Rebeca Kababie-Ameo, Facultad de Ciencias de la Salud, Centro de Investigación en Ciencias de la Salud, Universidad Anáhuac, Naucalpan de Juárez, Mexico, México, and others)
This compilation begins by discussing the common pediatric brain tumors, their key oncogenic drivers and signaling pathways. An update on the clinical trials against druggable targets is also provided.
An outline of the metabolizing pathways in cancer and the mode of action of aerobic glycolysis in cancer cells is presented, also highlighting the roles of nanotechnology in energy-based cancer therapies.
The authors review recent studies that characterize the specific mechanisms involved in mediating -tocotrienol reversal of epithelial-to mesenchymal transition in malignant breast cancer cells.
The cytotoxic effects of Mannich bases derived from kojic acid on A375 human malignant melanoma are discussed and MRC-5 human lung cell lines are investigated using a sulphorhodamine B assay.
Additionally, the cytotoxic effects and mechanisms displayed by metformin are assessed, alone or in combination with other agents. A better understanding of metformin-induced metabolic changes could aid in the discovery of new drugs, enhancing the efficacy of current melanoma therapeutics.
In closing, the authors explore the way in which physical activity and exercise are negatively correlated to most type of cancers, as exercise shares common underlying metabolic pathways with those of some bioactive food compounds, such as polyphenols.