Mitochondrial Function in Lung Health and Disease (Respiratory Medicine, Vol. 15)

ABOUT THIS BOOK

· Comprehensive, state-of-the-art review
· Written by experts in the field
· Covers both research and clinical issues

Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

Content Level » Professional/practitioner
Keywords » Biogenesis - Fibrosis - Lung health - Mitochondria - Pulmonary Arterial Hypertension- Sepsis
Related subjects » Biomedical Sciences - Internal Medicine

TABLE OF CONTENTS

Chapter 1
Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases
Harijith Anantha, Prasad Kanteti, Panfeng Fu, Sainath R. Kotha, Narasimham L. Parinandi, and Viswanathan Natarajan

Chapter 2Regulation of Mitochondrial Functions by Transcription Factor NRF2
Narsa Machireddy, Wajiha Qureshi, Haranath Potteti, Dhananjaya V. Kalvakolanu, and Sekhar P. Reddy

Chapter 3
Mitochondrion: A Missing Link in Asthma Pathogenesis
Ulaganathan Mabalirajan, Anurag Agrawal, and Balaram Ghosh

Chapter 4
ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea
Ganesh K. Kumar, Gayatri Raghuraman, and Nanduri R. Prabhakar

Chapter 5
Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle
Niccole Schaible, Philippe Delmotte, and Gary C. Sieck

Chapter 6
Mitochondrial Lipid Peroxidation in Lung Damage and Disease
Sainath R. Kotha, Travis O. Gurney, Miles U. Magalang, Thomas J. Hund, Abhay R. Satoskar, Peter J. Mohler, Krishna Rao Maddipati, Viswanathan Natarajan, and Narasimham L. Parinandi

Chapter 7
The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung
Lidza Kalifa and Michael A. O'Reilly

Chapter 8
Mitochondrial Function in Lung Health and Disease
Luis Puente-Maestu and Jorge Chancafe-Morgan

Chapter 9
Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial
DamageKatherine L. Tuggle and Michelle V. Fanucchi