This book describes the current status of the field of cellular therapy for neurological injuries, with primary areas of concentration on traumatic brain injury, stroke, (ischemic and hemorrhagic) as well as spinal cord injury. The book explores mechanisms of injury, the influence of the mechanism on the type of cell used, and the route of delivery/dosing regimen.
- Reviews strategies for cellular approaches to neurological injuries
- Provides guidelines for assessing and treatments for Traumatic Brain Injury (TBI)
- Contributing authors are leading researchers in a rapidly expanding field
Table of Contents
Overview of Neurological Injury: Common Themes. Pre-Clinical Models of TBI. Outcomes measures in pre-clinical models. Translational biomarkers in TBI. Neuroinflammatory reflex arc in TBI. Pathophysiology of TBI-Rationale for Cellular Therapies. Soluble Factors and MSC for TBI-TIMP-3. TSG-6 and soluble factors from MSCs after TBI. Spinal Cord Injury: Inflammation and implications for cell therapy. Cell therapy for Spinal Cord Injury: Rationale for cell types. Myelomengingocoele: In utero options for cellular therapies to improve neurological outcomes. Cellular Therapies for Ischemic Stroke. Hemorrhagic stroke: cellular therapies to enhance recovery.