Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature. This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death. That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models. This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic 'storm', that takes place during and following the induction of brain death, and how they impact metabolism. The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.
Chapter 1 Introduction Dimitri Novitzky and David K.C. Cooper Chapter 2 Historical Aspects of the Diagnosis of Death Felix Bacigalupo and Daniela Huerta Fernandez Chapter 3 The Determination of Brain Death Curtis M. Keller, Boris Chulpayev, and Michael Hoffmann Chapter 4 Legal Aspects of Declaration of Brain Death and Organ Donation Ricky T. Munoz and Mark D. Fox Chapter 5 Ethical Aspects of Declaration of Brain Death and Organ Donation Mark D. Fox and Ricky T. Munoz Chapter 6 Pathophysiology of Brain Death in Small Animal Models Bernhard Floerchinger, Nicholas L. Tilney, and Stefan G. Tullius Chapter 7 Pathophysiology of Brain Death and Effects of Hormonal Therapy in Large Animal Models Dimitri Novitzky, Winston N. Wicomb, and David K.C. CooperChapter 8The Efficacy of Thyroid Hormone Therapy in Brain-Dead Heart Donors: A Review of Thyroid Function in Health and Disease Lawrence E. Shapiro and Tatiana Baron Chapter 9 The Inflammatory Response to Brain Death Anne Barklin, Christine Lodberg Hvas, and Else Toennesen Chapter 10 The Influence of Brain Death and Intensive Care Management on Donor Organs: Assessment of Inflammatory Markers Wayel Jassem and Susan V. Fuggle Chapter 11 Brain-Death-Induced Inflammation: Possible Role of the Cholinergic Anti-Inflammatory Pathway Simone Hoeger and Benito A. YardChapter 12 Innate Immunity and Injury During Brain Death: Opportunities for Intervention Marc A. Seelen, Henri G.D. Leuvenink, and Rutger J. Ploeg Chapter 13Selection of the Brain-Dead Potential Organ Donor Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo Chapter 14 Infectious Disease Aspects of the Brain-Dead Potential Organ Donor Nicole M. Theodoropoulos and Michael G. Ison Chapter 15 Malignancy in the Brain-Dead Organ Donor Michael A. Nalesnik, Ron Shapiro, and Michael G. Ison Chapter 16 Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor Dimitri Novitzky, Burcin Ekser, and David K.C. Cooper Chapter 17 Assessment, Monitoring, and Management of the Brain-Dead Potential Organ Donor Demetrios Demetriades and Lydia Lam Chapter 18 Assessment, Monitoring and Management of Brain-Dead Potential Organ Donors in Europe Gabriel J. Echeverri and Bruno G. Gridelli Chapter 19 Current Management of Brain Dead Donors in Australia Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O'Callaghan, Helen Opdam, William Silvester, and Geoffrey J. Dobb (on behalf of the Australian Deceased Donor Management Research Group) Chapter 20 Management of the Brain-Dead Organ Donor-Perspectives of the Transplant Coordinator Nicole T. Farina and David K.C. Cooper Chapter 21 Surgical Aspects of Thoracic and Abdominal Organ Procurement from Brain-Dead Donors Michael J. Anstadt, Paul C. Kuo, and Kadiyala V. RavindraChapter 22 Impact of Brain Death on Storage of the Heart Winston N. Wicomb and David K.C. Cooper Chapter 23 Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera Chapter 24 Functional Repair of Brain Death-Induced Injury Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg Chapter 25 Functional Repair of Brain-Death-Injured Donor Lungs Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee Chapter 26 Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor Dimitri Novitzky and David K.C. Cooper Chapter 27 Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor Octavio E. Pajaro and James K. Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor-The Challenge Continues Eliezer Katz Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor-The Challenge Continues Eliezer Katz