Neoplastic Diseases of the Blood

About this Book

• An excellent general reference source spanning the range of hematologic neoplastic disorders from a clinical perspective
• Highly recommended to any practicing clinician with an interest in the diagnosis and treatment of hematologic malignant neoplasms
• A classic text that integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of neoplastic hematopathology

Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia— Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.

Content Level » Professional/practitioner

Keywords » Acute Leukemias - Bacterial Infection - Chronic Leukemias - Fungal Infection - Lymphoma - Myeloma - Stem Cell Therapy - Supportive Care - Viral Infection

Related subjects » Internal Medicine - Oncology & Hematology

Table of Contents

Part I: Chronic Leukemias and Related Disorders

• 1: A History of the Chronic Leukemias
  John M. Goldman and Myrtle Y. Gordon
• 2: Etiology and Epidemiology of Chronic Myeloid Leukemia
  Maren Rohrbacher and Joerg Hasford
• 3: Pathology of the Chronic Myeloid Leukemias
  Barbara J. Bain
• 4: Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia
  Alfonso Quintás Cardama, Hagop Kantarjian, and Jorge Cortes
• 5: Diagnosis and Treatment of Chronic Myeloid Leukemia
  Stephen G. O’Brien and John M. Goldman
• 6: Etiology and Epidemiology of CLL
  Dalemari Crowther-Swanepoel, Daniel Catovsky, and
  Richard S. Houlston
• 7: Histopathology, Morphology, and Immunophenotyping of CLL
  Abraham M. Varghese, Andy C. Rawstron, Roger G. Owen, and Peter Hillmen
• 8: Molecular Biology and Cytogenetics of Chronic Lymphocytic Leukemia
  David Oscier, Anne Gardiner, and Jonathan C. Strefford
• 9: Treatment of Chronic Lymphocytic Leukemia and Related Disorders
  Gautam Borthakur and Susan O’Brien
• 10: Hairy Cell Leukemia
  Sejal A. Jhatakia, Darren S. Sigal, and Alan Saven
• 11: The Pathogenesis, Diagnosis, and Treatment of Polycythemia Vera
  Mark A. Dawson and Brian J.P. Huntly
• 12: Diagnosis and Treatment of Essential Thrombocythemia and Primary Myelofibrosis
  John T. Reilly

Part II: Acute Leukemias

• 13: History of Acute Leukemia
  Emil J Freireich
• 14: The Etiology of Acute Leukemia
  Jessica N. Nichol, Sarit Assouline, and Wilson H. Miller
• 15: Epidemiology and Hereditary Aspects of Acute Leukemia
  Martha S. Linet, Graca M. Dores, Clara J. Kim, Susan S. Devesa, and Lindsay M. Morton
• 16: Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations
  Nukhet N. Tuzuner and John M. Bennett
• 17: Immunobiology of Acute LeukemiaElisabeth Paietta
• 18: Cytogenetics of Acute Leukemia
  Nyla A. Heerema and Susana Catalina Raimondi
• 19: Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia
  Dario Campana and Ching-Hon Pui
• 20: Diagnosis and Treatment of Adult Acute Lymphoblastic Leukemia
  Nicola Goekbuget and Dieter Hoelzer
• 21: Diagnosis and Treatment of Childhood Acute Myeloid Leukemia
  David A. Sweetser and Howard J. Weinstein
• 22: Diagnosis and Treatment of Adult Acute Myeloid Leukemia Other Than Acute Promyelocytic Leukemia
  Peter H. Wiernik
• 23: Acute Promyelocytic Leukemia
  Peter H. Wiernik, Robert E. Gallagher, and Martin S. Tallman
• 24: Therapy-Related Acute Myelogenous Leukemia
  Gabriela Bernadeta Iwanski, Nils Heinrich Thoennissen, Dorothy J. Park, and H. Phillip Koeffler
• 25: The Myelodysplastic Syndromes
  Kenneth Miller and Igor Rozenvald

Part III: Myeloma and Related Diseases

• 26: History of Multiple Myeloma
  David P. Steensma and Robert A. Kyle
• 27: Cytokines and Signal Transduction in Multiple Myeloma
  Dharminder Chauhan and Kenneth C. Anderson
• 28: Epidemiology of Multiple Myeloma
  Dalsu Baris, Linda Morris Brown, Gabriella Andreotti, and Susan S. Devesa
• 29: Immunoglobulins and Laboratory Recognition of Monoclonal Proteins
  Jerry Katzmann, Robert A. Kyle, John Lust, Melissa Snyder, and Angela Dispenzieri
• 30: Cytogenetic Abnormalities in MGUS and Myeloma
  Rafael Fonseca, P. Leif Bergsagel, and W. Michael Kuehl
• 31: Molecular Genetics of Myeloma
  Brian Van Ness
• 32: Prognosis and Staging of Multiple Myeloma
  Jesús F. San-Miguel, Ramón García-Sanz, and Norma C. Gutiérrez
• 33: Diagnosis and Treatment of Multiple Myeloma
  S.Vincent Rajkumar and Robert A. Kyle
• 34: Complications and Special Presentations of Plasma Cell Myeloma
  Joan Bladé and Laura Rosiñol
• 35: Waldenström’s Macroglobulinemia
  Efstathios Kastritis and Meletios A. Dimopoulos
• 36: Heavy-Chain Disease
  Dietlind L. Wahner-Roedler and Robert A. Kyle
• 37: Diagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis)
  Morie A. Gertz and Robert A. Kyle
• 38: Monoclonal Gammopathy of Undetermined Significance
  Robert A. Kyle and S. Vincent Rajkumar

Part IV: Lymphoma

• 39: Historical Landmarks in the Understanding of the Lymphomas
  Marshall A. Lichtman
• 40: Genetics in Lymphomagenesis
  Sigurdur Y. Kristinsson, Richard Rosenquist, Ola Landgren,
  Lynn R. Goldin, and Magnus Björkholm
• 41: Epidemiology and Hereditary Aspects of Hodgkin and Non-Hodgkin Lymphomas
  Seymour Grufferman
• 42: Pathology of Non-Hodgkin and Hodgkin Lymphomas
  L. Jeffrey Medeiros
• 43: Immunology of the Lymphomas
  Carla Kurkjian and Howard Ozer
• 44: Cytogenetics of Lymphomas
  Meaghan Wall and Lynda J. Campbell
• 45: Diagnosis and Treatment of Hodgkin’s
  Lymphoma
  Peter H. Wiernik, Monica Balzarotti, and Armando Santoro
• 46: Radiotherapeutic Management of Lymphomas
  John P. Plastaras, Eli Glatstein, Sandra E. Mitchell, and Nancy P. Mendenhall
• 47: Diagnosis and Treatment of Non-Hodgkin’s Lymphoma of Adults
  Edward A. Faber, Jr., Julie M. Vose, Philip J. Bierman, and James O. Armitage
• 48: Non-Hodgkin Lymphoma of Childhood
  Tony H. Truong, Sheila Weitzman, and Robert J. Arceci
• 49: Lymphoma in Other Diseases
  William B. Ershler, Barbara K. Dunn, and Dan L. Longo

Part V: Supportive Care

• 50: Supportive Care for Patients with Leukemia: A Historical Perspective
  Charles A. Schiffer
• 51: Prevention of Infections in Patients with Hematological Malignancies
  Marcio Nucci, Elias J. Anaissie, Maria Cecilia Dignani, and Tahsine Mahfouz
• 52: Evaluation and Management of Bacterial and Fungal Infections Occurring in Patients with a Hematological Malignancy: A 2011 Update
  James C. Wade
• 53: Viral Infections in Patients with Hematological Malignancies
  Jack W. Hsu, John W. Hiemenz, John R. Wingard, and Helen Leather
• 54: Therapeutic Cytapheresis, Plasmapheresis, and Plasma Exchange in Neoplastic Diseases
  of the Blood
  Janice P. Dutcher
• 55: Red Cell Transfusions in Patients with Hematologic Malignancies
  Karen E. King and Paul M. Ness
• 56: Platelet and Granulocyte Transfusion
  Janice P. Dutcher
• 57: Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications
  Jonathan A. Gutman, Shelly Heimfeld, and H. Joachim Deeg
• 58: HLA Typing in Support of Hematopoietic Cell Transplantation from Unrelated Donors
  Effie W. Petersdorf, Claudio Anasetti, Paul J. Martin, and John A. Hansen
• 59: Special Care of Blood and Marrow Stem Transplant Patients
  Hillard M. Lazarus, Lisa M. Arfons, and Richard J. Creger
• 60: Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with
  Hematologic Neoplasms
  Belinda R. Avalos and Edward Copelan
• 61: Bleeding and Thrombosis in Hematologic Neoplasia
  Aleksandra Ciszewski and Thomas DeLoughery
• 62: Psychological Aspects of Hematological Neoplasms
  Tomer T. Levin

Index