Electrical Disease of the Heart, 2nd Edition, volume 1, provides a valuable insight to the latest developments in the field of cardiac electrophysiology and clinical electrocardiology. Each chapter includes up-to-date results of studies aimed at providing an understanding of the electrical function of the heart in health and disease, established and evidence-based knowledge of clinical outcomes, areas of controversy, and future trends. This book is highly relevant to a broad audience, ranging from medical and graduate students, to clinicians and scientists.
Basic Cardiac Electrophysiology- Promises Kept and Promises to Keep.- Basic Physiology of Ion Channel Function.- Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form.- Anatomic and Histopathologic Characteristics of the Conductive Tissues of the Heart.- Neural Regulation of the Heart in Health and Disease.- Mechanisms of Cardiac Arrhythmia.- Mechanisms of Action of Antiarrhythmic Drugs in Ventricular Arrhythmias.- Mechanisms of Action of Antiarrhythmic Drugs in Atrial Fibrillation.- Mechano-Electrical Interactions and their Role in Electrical Function of the Heart.- Pathological Roles of the Cardiac Sodium Channel Late Current (late INa).- Sodium Ion Channelopathies.- L-Type Calcium Channel Disease.- Nerve Sprouting, Defibrillation and Calcium Waves.- K+ Channelopathies (IKs, IKr, and Ito).- Cardiac ATP-Sensitive Potassium Channels and Associated Channelopathies.- Cardiac KATP Channels in Health and Diseases.- Ca2+ Release Channels (Ryanodine Receptors) and Arrhythmogenesis.- Caveolae and Arrhythmogenesis.- Senescence and Arrhythmogenesis.- Comparisons of Substrates Responsible for Atrial versus Ventricular Fibrillation.- Single Nucleotide Polymorphisms in Health and Cardiac Disease.- Electrophysiological Remodeling in Heart Failure.- Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy.- Physiological and Other Biological Pacemakers.- Cardiac Memory: From Electrical Curiosity to Clinical Diagnostic and Research Tool.- Heritable Arrhythmogenic Channelopathies, Primary Electrical Diseases, and Sudden Cardiac Death.- Celebrating the Challenge of Cardiac Arrhythmias.- Congenital Long QT Syndrome.- Brugada Syndrome - Clinical and Genetic Aspects.- Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy.- Early Repolarization Syndrome: Epidemiology, Genetics, and Risk Stratification.- Catecholaminergic Polymorphic Ventricular Tachycardia.- Andersen-Tawil and Timothy Syndromes.- Short QT Syndrome.- Progressive Cardiac Conduction Disease.- Genetics of Atrial Fibrillation.- Idiopathic Ventricular Fibrillation.
Ihor Gussak, MD, PhD, Charles Antzelevitch, PhD, FACC, FAHA, FHRS, Arthur A.M. Wilde, MD, PhD, Brian D. Powell, MD, Michael J. Ackerman, MD, PhD and Win-Kuang Shen, MD