Molecular Determinants of Radiation Response

About this book

The DNA of mammalian cells is constantly under assault from both endogenous and exogenous sources. Ionizing radiation is one of the most important sources of genomic injury because of its ability to inflict substantial cellular damage that is both therapeutic as well as mutagenic. Mammalian cells have evolved an impressive array of DNA damage response mechanisms that are called upon to respond to and repair radiation-induced DNA injury that allow cells to survive with DNA fidelity intact. Contemporary oncologic research and patient management demand a thorough understanding of these DNA damage response processes as well as some of the important environmental conditions like hypoxia in which cells exist such that strategies that subvert these survival processes can be considered and exploited for therapeutic gain.

Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. The authors have done a wonderful job in providing meaningful reviews, with appropriate detail and scope for both the well informed reader as well as the novice looking for new information. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Content Level » Research
Related subjects » Cancer Research - Pharmaceutical Science

Table of contents

Molecular Basis of the DNA Damage Responses

1) H2AX in DNA Damage Response
Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Sedelnikova, and William M. Bonner

2) DNA Damage Signaling Downstream of ATM
Fred Bunz

3) Checkpoint Control Following Radiation Exposure
Markus Lobrich, Aaron A. Goodarzi, Tom Stiff and Penny A. Jeggo

4) Chromatin Responses to DNA Damage
Xuetong Shen and Karina Falbo

5) C. elegans and Radiation Responses
Aymeric Bailly and Anton Gartner

Modulation of Radiation Responses – Opportunities for Therapeutic Exploitation

6) Hypoxia and Modulation of Cellular Radiation Response
Ester M. Hammond, Monica Olcina and Amato J. Giaccia

7) Inhibitors of DNA Repair and Response to Ionising Radiation
Barbara Vischioni, Nils H. Nicolay, Ricky A. Sharma and Thomas Helleday

8) Gene Therapy and Radiation
Svend O. Freytag, Kenneth N. Barton, Farzan Siddiqui, Mohamed Elshaikh, Hans Stricker and Benjamin Movsas

9) Molecular Targeted Drug Delivery Radiotherapy
Eugenia M. Yazlovitskaya and Dennis E. Hallahan

10) EGFR Signaling and Radiation
Emily F. Dunn, Shyhmin Huang, and Paul M. Harari

11) Thermal Modulation of Radiation-Induced DNA Damage Response
Joseph L. Roti Roti, Robert P. VanderWaal and Andrei Laszlo

12) Radiation-induced Immune Modulation
Charles Drake