In this book, Vitali Sintchenko brings together a collection of state-of-the-art reviews of informatics applications aiming to improve the diagnosis, prevention, treatment and control of infectious diseases. In response to the need for computational biology techniques geared towards clinical medicine, this volume covers the emerging domains of translational bioinformatics, genomics enabled decision support, intelligent design of vaccines and antimicrobial drugs as well as new types of biosurveillance. This book is written by a diverse, international group of experts in the field and provides clinicians, pathologists, biomedical researchers and informaticians with an essential resource that offers also a fascinating glimpse into the future of this dynamic field.
Vitali Sintchenko (MBBS, PhD, FRCPA, FACHI) is a clinical microbiologist and informatician with the Sydney Medical School, The University of Sydney, Australia.
Written for: Academic bioinformaticians, computational biologists and researchers in health informatics, public health microbiologists and epidemiologists; biomedical researchers in the pharmaceutical industry, researchers working on developing diagnostic software, graduate students studying and researching in comparative genomics and computational approaches to public health issues
Table of contents
Preface.- List of contributors.- 1 Informatics for Infectious Disease Research and Control.- 2 Bioinformatics of Microbial Sequences.- 3 Mining Databases for Microbial Gene Sequences.- 4 Comparative Genomics of Pathogens.- 5 Systems Microbiology: Gaining Insights in Transcriptional Networks.- 6 Host-Pathogen Systems Biology.- 7 Text Mining for Discovery of Host-Pathogen Interactions.- 8 A Network Approach to Understanding Pathogen Population Structure: from Host Networks to Antigen Networks.- 9 Computational Epitope Mapping.- 10 Pangenomic Reverse Vaccinology.- 11 Immunoinformatics: The Next Step in Vaccine Design.- 12 Understanding the Shared Bacterial Genome.- 13 Computational Grammars for Annotation and Interrogation of Mobile Genetic Elements.- 14 In silico Discovery of Chemotherapeutic Agents.- 15 Informatics for Healthcare Epidemiology.- 16 Automated, High-throughput Surveillance Systems for Public Health.- 17 Microbial Genotyping Systems for Infection Control.- 18 Temporal and Spatial Clustering of Bacterial Genotypes.- 19 Infectious Disease Ontology.- 20 Populations, patients, germs and genes – ethics of genomics and informatics in communicable disease control.- Glossary.