Computational Cardiovascular Mechanics promotes the application of patient-specific cardiovascular mechanics models to clinical medicine, which aid medical diagnosis and enhance treatment for cardiovascular disease.
Organized in a two-part structure, this volume presents a comprehensive overview of computational modeling from both solid mechanics and fluid dynamics perspectives. Part I offers chapters devoted to various techniques involving finite element modeling of ventricular mechanics and computational fluid dynamics, with a focus in cardiovascular mechanics. Part II covers heart failure applications which utilize techniques in solid mechanics and fluid dynamics. In the former, both diagnostic (i.e., global and regional indices of myocardial contractility) as well as therapeutic approaches (surgical ventricular remodeling procedures, passive ventricular constraint devices, ventricular implantation of biomaterials and cardiac resynchronization therapy) are discussed. In the latter, the fluid mechanics of heart valves is simulated, as are surgical procedures and heart failure-related devices in the form of coronary artery bypass grafting and ventricular assist devices.
Computational Cardiovascular Mechanics is a vital resource for cardiovascular disease researchers who want to learn how to apply computational fluid and/or solid mechanics to the diagnosis and treatment of heart failure.
Written for: Researchers and physicians in the fields of biomedical and mechanical engineering
computational fluid dynamics
finite element method
finite element modeling
fluid structure interaction
Table of contents
Foreword.- Preface.- Introduction.- Part I: Computational Modeling of Cardiovascular Mechanics- In-Vivo Left Ventricular Geometry and Boundary Conditions.- Image-Based Assessment and Modeling of Structures of the Myocardium.- Constitutive Equations and Model Validation.- Determination of Myocardial Material Properties by Optimization.- Computational Models of Cardiac Electrical Activation.- Geometrical Feature of the Vascular System.- Vascular Geometry Reconstruction and Grid Generation.- Governing Equations of Blood Flow and Respective Numerical Methods.- Fluid-Structure Interaction Modeling in the Cardiovascular System.- Turbulence in the Cardiovascular System: Aortic Aneurysm as an Illustrative Example.- Part II: Applications in Heart Failure- Noninvasive Assessment of Left Ventricular Remodeling: Geometry, Wall Stress and Function.- Surgical Left Ventricular Remodeling Procedures.- Passive Left Ventricular Constraint Devices.- Left Ventricular Implantation of Biomaterials.- Computational Modeling of Heart Failure with Application to Cardiac Resynchronization Therapy.- Computational Modeling of Aortic Heart Valve Mechanics Across Multiple Scales.- Blood Flow in an Out-of-Plane Aorto-Left Coronary Sequential Bypass Graft.- Computational Fluid Dynamics Models of Ventricular Assist Devices.