Pediatric and Adolescent Osteosarcoma provides a review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in epidemiology and etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age groups, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome.
In essence the scope and intensive coverage of the book provides a historical perspective of the advances made over the past 30 years and emerging concepts and prospects for new diagnostic and therapeutic approaches. This is based upon past experiences and new discoveries. It also provides a unique opportunity for pediatric and adult medical oncologists, physicians in training, orthopedic surgeons, pathologists, radiologists, radiotherapists, oncology nurses and allied professionals involved in the care of pediatric/adolescent patients with osteosarcoma to become acquainted with prevailing methods of treatment and new and evolving concepts and developments.
"Osteosarcoma is the most common primary bone malignancy. Remarkable advances have occurred in the management of this cancer over the last two decades. In this text experts in the field discuss the most pertinent biologic and clinical issues relevant to the disease." - Steven T. Rosen, M.D. Series Editor
Written for: Pediatric and adult medical oncologists, physicians
in training, orthopedic surgeons, pathologists, radiologists, radiotherapists,
oncology nurses, and allied professionals involved in the care of pediatric/adolescent
patients with osteosarcoma
soft tissue sarcomas
Table of contents
The Epidemiology of Osteosarcoma.- The Etiology of Osteosarcoma.- Imaging Assessment of Osteosarcoma in Childhood and Adolescence.- Conditions Mimicking Osteosarcoma.- Surgical Management of Primary Osteosarcoma.- Osteosarcoma Multidisciplinary Approach to the Management from the Pathologist's Perspective.- The Role of Radiotherapy in Osteosarcoma.- Osteosarcoma Lung Metastases Detection and Principles of Multimodal Therapy.- Surgical Treatment of Pulmonary Metastases from Osteosarcoma in Pediatric and Adolescent Patients.- Non-Surgical Treatment of Pulmonary and Exra-pulmonary Metastases.- Adjuvant Chemotherapy in Osteosarcoma.- Osteosarcoma: Review of the Past, Impact on the Future: The American Experiences.- Osteosarcoma: The European Osteosarcoma Intergroup (EOI) Perspective.- The Treatment of Non-Metastatic High Grade Osteosarcoma of the Extremity: Review of the Italian Rizzoli Experience: Impact on the Future.- Osteosarcoma: The Coss Experience.- Treatment of Osteosarcoma: The Scandinavian Sarcoma Group Experience.- Childhood Osteosarcoma.- International Collaboration is Feasible in Trials for Rare Conditions: The EURAMOS Experience.- Pediatric and Adult Osteosarcoma: Comparisons and Contrasts in Presentation and Therapy.- The Role of Physical Therapy and Occupational Therapy in the Rehabilitation of Pediatric and Adolescent Patients with Osteosarcoma.- Caring for Children and Adolescents with Osteosarcoma.- Prosthetics for Pediatric and Adolescent Amputees.- Functional, Psychosocial and Professional Outcomes in Long-Term Survivors of Lower-Extremity Osteosarcomas: Amputation Versus Limb Salvage.- Bridging the Gap between Experimental Animals and Humans in Osteosarcoma.- Is There a Role for Immunotherapy in Osteosarcoma?- Molecular Classification of Osteosarcoma.- Current Concepts on the Molecular Biology of Osteosarcoma.- How the NOTCH Pathway Contributes to the Ability of Osteosarcoma Cells to Metastasize.- The Role of Fas/FasL in the Metastatic Potential of Osteosarcoma and Targeting this Pathway for the Treatment of Osteosarcoma Lung Metastases.- Bone Marrow Micrometastases Studied by an Immunomagnetic Isolation Procedure in Extremity Localized Non-metastatic Osteosarcoma Patients.- Strategies to Explore New Approaches in the Investigation and Treatment of Osteosarcoma.- History of Orthopaedic Oncology in the USA.- Editorial Summation.- Index.