Neurotoxicology

This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson's or Alzheimer's disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.

Key topics include:

• completely revised content with new contributors and new illustrations, including a full-color insert
• new state-of-the-science technologies
• new areas of research and alternative model systems
• up-to-date coverage of epidemiology, model systems, mechanisms of action, assessment of risk, and cellular approaches to neurotoxicology
• metabolic influences on neurotoxicity
• role of free radical formation in neurotoxicity
• interaction between chemicals and trophic factors
• endocrine disruptors
• apoptosis in neurotoxicity
• in vivo brain imaging
• advances in measuring cognitive function
• advances in developing quantitative models for neurotoxicology/risk assessment