This new edition aims to explore the molecular mechanisms underlying insulin resistance and the metabolic syndrome, and to demonstrate how metabolic disorders such as diabetes, obesity, hypertension, and disturbances in lipid/carbohydrate metabolism, can be directly linked to cardiovascular disease. Secondly, it explains how therapeutic lifestyle changes and pharmacologic interventions are effective at improving insulin resistance and therefore reduce the threat of cardiovascular problems, and has sections highlighting the clinical outcomes of the various treatments.
Fully comprehensive in both the science and research behind the metabolic syndrome, and also the treatments methods and preventative strategies used by clinicians when dealing with patients, this book is perfect for cardiovascular and endocrinologists alike, at both the bench and the bedside level. The book will be ideal equally for both cardiovascular and endocrinology clinicians and researchers. Researchers will use it to educate themselves in the current mechanistic insights on the derivation of the metabolic syndrome, insulin resistance and its comorbidities. Clinicians will use it to improve their prevention of metabolic disorders in patients and in order to treat and manage the syndrome and its complications according to current clinical guidelines.
Table of Contents
- 1. Introduction.
- 2. Insulin and Glucagon.
- CAUSES OF INSULIN RESISTANCE.
- 3. Oxidative Stress.
- 4. Inflammation.
- 5. Mental Stress.
- 6. Adipose Tissue and Obesity.
- 7. Adipokines of Adipose Tissue.
- 8. Mitochondrial Dysfunction.
- 9. Insulin Resistance and the Metabolic Syndrome.
- TARGETS AND MANIFESTATIONS OF INSULIN RESISTANCE.
- 10. The Endothelium and Nitric Oxide.
- 11. Skeletal Muscle.
- 12. Lipids and Atherogenic Dyslipidemia.
- 13. Comorbidities of the Metabolic Syndrome.
- 14. Survival and Longevity.
- 15. Peroxisome Proliferator-Activated Receptors.
- 16. Exercise and Meditation.
- 17. Weight Loss.
- 18. Diet and supplements.
- 19. Pharmacology.