Parkinson’s Disease has traditionally been seen as a movement disorder, and diagnosed by the development of tremor. However, we are beginning to understand that the disease manifests itself in many ways, and that earlier diagnosis might be possible through non-tremor symptoms. This textbook aims to tell the full story of non-motor and non-dopaminergic features of Parkinson’s Disease.
Table of Contents
Chapter 1 The Dopaminergic and Non-Dopaminergic Features of Parkinson’s
Disease (C.W. Olanow, F Stocchi, and AE Lang).
Chapter 2 Neuropathologic Involvement of the Dopaminergic Neuronal Systems in Parkinson’s Disease (Daniel P. Perl).
Chapter 3 Non-dopaminergic Pathology of Parkinson’s Disease (Heiko Braak and Kelly Del Tredici).
Chapter 4 Functional Anatomy of the Motor and Non-Motor Circuitry of the Basal Ganglia (Yoland Smith).
Chapter 5 The functional organization of the basal ganglia: Dopaminergic and Non-Dopaminergic Features (Carlos Juri, Maria C. Rodriguez-Oroz, and Jose A. Obeso).
Chapter 6 Anatomy and Physiology of Limbic System Dysfunction in Parkinson’s Disease (Anthony A. Grace).
Chapter 7 Animal Models of Parkinson’s disease: the non-motor and non-dopaminergic features (Katherine E. Soderstrom, Shilpa Ramaswamy, C. Warren Olanow, and Jeffrey H. Kordower).
Chapter 8 The Emerging Entity of Pre-motor Parkinson’s Disease (J. William Langston).
Chapter 9 Functional Imaging Studies in Parkinson’s Disease: The Non-Dopaminergic Systems (A Jon Stoessl).
Chapter 10 Assessment of non-motor features of Parkinson’s Disease: Scales and Rating Tools (Christopher G. Goetz and Cristina Sampaio).
Chapter 11 Clinical Trial Measures of the Non-Motor Features of Parkinson’s Disease (Karl Kieburtz).
Chapter 12 Clinical Features of Dementia Associated with Parkinson’s Disease and Dementia with Lewy Bodies (David J. Burn).
Chapter 13 Neuropsychological Features of Parkinson’s Dementias (Leonardo Cruz de Souza, Virginie Czernecki, and Bruno Dubois).
Chapter 14 Neuropathology of Dementia in Parkinson’s Disease (Dennis W. Dickson and Carolyn F. Orr).
Chapter 15 Treatment of Dementia Associated with Parkinson’s Disease (Murat Emre).
Chapter 16 Psychosis in Parkinson’s Disease (Joe Friedman).
Chapter 17 Depression in Parkinson Disease (Tiffini Voss and Irene Hegeman Richard).
Chapter 18 Anxiety Syndromes and Panic Attacks (Daniel Weintraub and Staci Stewart).
Chapter 19 The Dopamine Dysregulation Syndrome (Sean S. O’Sullivan and Andrew J. Lees).
Chapter 20 Neurobiology of Impulse Control Disorders in Parkinson’s Disease (T.D.L. Steeves, Janis Miyasaki , Anthony E. Lang and Antonio P. Strafella).
Chapter 21 Sleep Disorders in Parkinson’s Disease (Friederike Sixel-Döring & Claudia Trenkwalder).
Chapter 22 Neuronal Mechanisms of REM Sleep and Their Role in REM Sleep Behavior Disorder (Jun Lu and Clifford B. Saper).
Chapter 23 REM Sleep Behavior Disorder and Neurodegenerative Disorders (Mark W. Mahowald, Carlos H. Schenck, and Michel A. Cramer Bornemann).
Chapter 24 Gastrointestinal and Swallowing Disturbances in Parkinson’s Disease (Ronald F. Pfeiffer).
Chapter 25 Bladder Dysfunction in Parkinson’s Disease (Fabrizio Stocchi, Margherita Torti, Giovanni Palleschi and Antonio Carbone).
Chapter 26 Orthostatic Hypotension in Parkinson’s Disease (Uday Muthane and Christopher J Mathias).
Chapter 27 Sexual Dysfunction (Kimberly Pargeon, Karen Anderson and William J. Weiner).
Chapter 28 Olfactory Dysfunction (John E. Duda and Matthew B. Stern).
Chapter 29 Pain and Paresthesia in Parkinson’s Disease (Shen-Yang Lim and Andrew H. Evans).
Chapter 30 Restless Legs Syndrome and Akathisia in Parkinson’s Disease (Alex Iranzo and Cynthia L. Comella).
Chapter 31 Speech and Voice Disorders in Parkinson’s Disease (Lorraine Ramig, Cynthia Fox, and Shimon Sapir).
Chapter 32 Gait, Postural Instability and Freezing (Yvette A.M. Grimbergen, Arlène D. Speelman, Marjolein A. van der Marck, Yvonne Schoon and Bastiaan R. Bloem).
Chapter 33 Orthopedic Complications of Parkinson’s Disease (Joseph Rudolph and Michele Tagliati).
Chapter 34 Other Non-motor Symptoms of Parkinson’s Disease (Mark Edwards and Kailash Bhatia).
Chapter 35 Overview of the Medical Treatment of the Non-motor and Non-Dopaminergic Features of Parkinson’s Disease (Mark Stacy and Joseph Jankovic).
Chapter 36 Surgery for Non-dopaminergic and Non-motor Features of Parkinson’s Disease (Brian J. Snyder and Andres M. Lozano).
Chapter 37 The Effects of Exercise on Basal Ganglia Function in Parkinson’s Disease and its Animal Models (Giselle M. Petzinger, Beth E. Fisher, Charlie K. Meshul, John P. Walsh, Garnik Akopian, and Michael W. Jakowec).
Chapter 38 Non-dopaminergic Approaches to the Treatment of Parkinson’s Disease (Susan H Fox and Jonathan M Brotchie).
Chapter 39 Prospects for Neuroprotective Therapies that can Modulate Non-Dopaminergic Features in PD (C. Warren Olanow and Anthony E. Lang).
C. Warren Olanow, MD, Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
Fabrizio Stocchi, MD Institute of Neurology, IRCCS San Raffaele Pisana, Rome, Italy
Anthony E. Lang, MD, Division of Neurology, University of Toronto, Toronto, Canada