


Vaccinology. Principles and Practice
Morrow, J. — Sheikh, N. — Schmidt, C. — Davies, H.
1ª Edición Agosto 2012
Inglés
Tapa dura
552 pags
1600 gr
x x cm
ISBN 9781405185745
Editorial WILEY
Recíbelo en un plazo De 7 a 10 días
Description
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.
- Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
- Includes evaluation of vaccine efficacy and safety
- Details clinical trial design, including regulatory requirements
- Discusses the emerging field of active cellular immunotherapy
Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
Table of Contents
- List of Contributors
- Preface
Part 1 Introduction
- 1. Concept and Scope of Modern Vaccines
D. Huw Davies, Clint S. Schmidt, & Nadeem A. Sheikh
Part 2 Principles of Vaccine Design
- 2. Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants
Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, & Volker Gerdts - 3. Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules
Antony N. Antoniou, Izabela Lenart, David B. Guiliano, & Simon J. Powis - 4. Understanding the Mucosal Immune System for Better Mucosal Vaccine Design
Janine Bilsborough & Joanne L. Viney - 5. Immunologic Memory: T Cells in Humans
Maria Candela Iglesias, Victor Appay, & Arnaud Moris - 6. Immunologic Memory: B cells
F. Eun-Hyung Lee & I ˜ naki Sanz - 7. Utility of Mouse Models in Vaccine Design and Development
Catharine M. Bosio, Megan MacLeod, Philippa Marrack, & Ross M. Kedl - 8. Utility of Nonhuman Primate Models for Vaccines
Preston A. Marx, Jr & Alexander F. Voevodin
Part 3 Antigen Discovery
- 9. Sequence-Based Computational Approaches to Vaccine Discovery and Design
Darrick Carter - 10. Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies
D. Huw Davies - 11. Phage Libraries
Aaron K. Sato
Part 4 Antigen Engineering
- 12. Attenuated Bacterial Vaccines
Richard W. Titball & Helen S. Atkins - 13. Virus-like Particles as Antigen Scaffolds
Bryce Chackerian & John T. Schiller - 14. Recombinant MVA vaccines: Optimization, Preclinical, and Product Development
Yper Hall & Miles W. Carroll - 15. Recombinant Adenoviruses for Vaccination
Nelson Cesar Di Paolo, Dmitry Shayakhmetov, & Andr´e Lieber - 16. Recombinant Avipoxviruses
Michael A. Skinner & Stephen M. Laidlaw - 17. Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy
Patrick Guirnalda, Laurence Wood, Matthew Seavey, & Yvonne Paterson - 18. Nucleic Acid Vaccination
Britta Wahren & Margaret A. Liu - 19. Artificial Antigen-presenting Cells: Large Multivalent Immunogens
Matthew F. Mescher & Julie M. Curtsinger
Part 5 Delivery Systems
- 20. Transcutaneous Immunization via Vaccine Patch Delivery System
Robert C. Seid, Jr & Gregory M. Glenn - 21. Needle-free Jet Injection for Vaccine Administration
Brian R. Sloat, Hoi K. Tran, & Zhengrong Cui - 22. Oral Vaccines: An Old Need and Some New Possibilities
Amit A. Lugade, Kalathil Suresh, & Yasmin Thanavala - 23. Adjuvants: From Serendipity to Rational Discovery
Derek T. O’Hagan & Andreas Wack - 24. Immunostimulatory Properties of Biodegradable Microparticles
Fiona A. Sharp & Ed C. Lavelle - 25. Co-administration of Co-stimulatory Moieties
Carolina Arancibia-C ´arcamo & Yvette Latchman - 26. Toll Receptors in Relation to Adjuvant Effects
Dipshikha Chakravortty, Amit Lahiri, & Priyanka Das
Part 6 Regulatory Considerations
- 27. Regulatory Issues (FDA and EMA)
Murrium Ahmad, Victoria Byers, & Peter Wilson
Part 7 Evaluating Vaccine Efficacy
- 28. Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine
Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton, & Camilla Jandus - 29. Clinical Development Strategy: Nuts and Bolts
Candida Fratazzi & Claudio Carini - 30. Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification
Robert Rees, Stephanie Laversin, Cliff Murray, & Graham Ball
Part 8 Implementing Immunizations/Therapies
- 31. Mass Immunization Strategies
David L. Heymann, R. Bruce Aylward, & Rudolf H. Tangermann - 32. The Role of Mathematical Models in Vaccine Development and Public Health Decision Making
Marie-Claude Boily, Marc Brisson, Benoit Mˆ asse, & Roy M. Anderson - 33. Vaccine Safety
John Iskander, Claudia Vellozzi, Jane Gidudu, & Robert T. Chen
Index
Author
W. John W. Morrow, Seattle, Washington, USA
Nadeem A. Sheikh, Dendreon, Inc., Seattle, Washington, USA
Clint S. Schmidt, NovaDigm Therapeutics, Inc., Grand Forks, North Dakota, USA
D. Huw Davies, University of California at Irvine, USA
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