Vaccinology. Principles and Practice

Description

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.

• Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
• Includes evaluation of vaccine efficacy and safety
• Details clinical trial design, including regulatory requirements
• Discusses the emerging field of active cellular immunotherapy

Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Table of Contents

• List of Contributors
• Preface

Part 1 Introduction

• 1. Concept and Scope of Modern Vaccines
  D. Huw Davies, Clint S. Schmidt, & Nadeem A. Sheikh

Part 2 Principles of Vaccine Design

• 2. Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants
  Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, & Volker Gerdts
• 3. Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules
  Antony N. Antoniou, Izabela Lenart, David B. Guiliano, & Simon J. Powis
• 4. Understanding the Mucosal Immune System for Better Mucosal Vaccine Design
  Janine Bilsborough & Joanne L. Viney
• 5. Immunologic Memory: T Cells in Humans
  Maria Candela Iglesias, Victor Appay, & Arnaud Moris
• 6. Immunologic Memory: B cells
  F. Eun-Hyung Lee & I ˜ naki Sanz
• 7. Utility of Mouse Models in Vaccine Design and Development
  Catharine M. Bosio, Megan MacLeod, Philippa Marrack, & Ross M. Kedl
• 8. Utility of Nonhuman Primate Models for Vaccines
  Preston A. Marx, Jr & Alexander F. Voevodin

Part 3 Antigen Discovery

• 9. Sequence-Based Computational Approaches to Vaccine Discovery and Design
  Darrick Carter
• 10. Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies
  D. Huw Davies
• 11. Phage Libraries
  Aaron K. Sato

Part 4 Antigen Engineering

• 12. Attenuated Bacterial Vaccines
  Richard W. Titball & Helen S. Atkins
• 13. Virus-like Particles as Antigen Scaffolds
  Bryce Chackerian & John T. Schiller
• 14. Recombinant MVA vaccines: Optimization, Preclinical, and Product Development
  Yper Hall & Miles W. Carroll
• 15. Recombinant Adenoviruses for Vaccination
  Nelson Cesar Di Paolo, Dmitry Shayakhmetov, & Andr´e Lieber
• 16. Recombinant Avipoxviruses
  Michael A. Skinner & Stephen M. Laidlaw
• 17. Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy
  Patrick Guirnalda, Laurence Wood, Matthew Seavey, & Yvonne Paterson
• 18. Nucleic Acid Vaccination
  Britta Wahren & Margaret A. Liu
• 19. Artificial Antigen-presenting Cells: Large Multivalent Immunogens
  Matthew F. Mescher & Julie M. Curtsinger

Part 5 Delivery Systems

• 20. Transcutaneous Immunization via Vaccine Patch Delivery System
  Robert C. Seid, Jr & Gregory M. Glenn
• 21. Needle-free Jet Injection for Vaccine Administration
  Brian R. Sloat, Hoi K. Tran, & Zhengrong Cui
• 22. Oral Vaccines: An Old Need and Some New Possibilities
  Amit A. Lugade, Kalathil Suresh, & Yasmin Thanavala
• 23. Adjuvants: From Serendipity to Rational Discovery
  Derek T. O’Hagan & Andreas Wack
• 24. Immunostimulatory Properties of Biodegradable Microparticles
  Fiona A. Sharp & Ed C. Lavelle
• 25. Co-administration of Co-stimulatory Moieties
  Carolina Arancibia-C ´arcamo & Yvette Latchman
• 26. Toll Receptors in Relation to Adjuvant Effects
  Dipshikha Chakravortty, Amit Lahiri, & Priyanka Das

Part 6 Regulatory Considerations

• 27. Regulatory Issues (FDA and EMA)
  Murrium Ahmad, Victoria Byers, & Peter Wilson

Part 7 Evaluating Vaccine Efficacy

• 28. Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine
  Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton, & Camilla Jandus
• 29. Clinical Development Strategy: Nuts and Bolts
  Candida Fratazzi & Claudio Carini
• 30. Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification
  Robert Rees, Stephanie Laversin, Cliff Murray, & Graham Ball

Part 8 Implementing Immunizations/Therapies

• 31. Mass Immunization Strategies
  David L. Heymann, R. Bruce Aylward, & Rudolf H. Tangermann
• 32. The Role of Mathematical Models in Vaccine Development and Public Health Decision Making
  Marie-Claude Boily, Marc Brisson, Benoit Mˆ asse, & Roy M. Anderson
• 33. Vaccine Safety
  John Iskander, Claudia Vellozzi, Jane Gidudu, & Robert T. Chen

Index

Author

W. John W. Morrow, Seattle, Washington, USA
Nadeem A. Sheikh, Dendreon, Inc., Seattle, Washington, USA
Clint S. Schmidt, NovaDigm Therapeutics, Inc., Grand Forks, North Dakota, USA
D. Huw Davies, University of California at Irvine, USA