


Leukemias. Principles and Practice of Therapy
Faderl, S. — Kantarjian, H.
ISBN-13: 9781405182355
WILEY
Diciembre / 2010
1ª Edición
Inglés
Tapa dura
456 pags
2000 gr
23 x 28 x 3 cm
Recíbelo en un plazo De 7 a 10 días
Description
Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials.
Topics include:
- Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors)
- Ras inhibitors
- Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors)
- Lenalidomide analogs
- New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine
- Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib)
- New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40)
- Thrombopoietic agents
Leukemias: Principles and Practice of Therapy
- Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease
- Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area
Table of Contents
Part 1: Background and Diagnostic.
- 1. Stem Cell Biology in Normal and Malignant Hematopoiesis (Amer Zeidan and Meir Wetzler).
- 2. Epidemiology and Etiology of Leukemias (Andrew Fletcher, Annika Whittle and David Bowen).
- 3. Traditional Diagnostic Approaches (Hartmut Koeppen, Carlos E. Bueso-Ramos and Sergej N. Konoplev).
- 4. Diagnosis of Leukemias - New Diagnostic Modalities and Implications for Classification (Maher Albitar).
- 5. Non-cytogenetic Markers and Their Impact on Prognosis (Eric Schafer and Donald Small).
Part 2: Myelodysplastic syndromes (MDS).
- 6. Myelodysplastic Syndromes: Pathophysiology (Steven D. Gore and Erica Warlick).
- 7. Myelodysplastic Syndromes - The Role of Cytogenetic and Molecular Abnormalities for Classification and Risk Assignment (Ulrich Germing).
- 8. Myelodysplastic Syndromes (William Stevenson and Guillermo Garcia-Manero).
Part 3: Acute Myeloid Leukemia (AML).
- 9. Presentation and Diagnosis: Novel Molecular Markers and their Role in the Prognosis and Therapy of Acute Myeloid Leukemia (Wolfgang Kern, Torsten Haferlach, Susanne Schnittger, Claudia Haferlach, and Ulrike Bacher).
- 10. Induction Therapy of Acute Myeloid Leukemia (Martha Wadleigh and Daniel J. DeAngelo).
- 11. Salvage Therapy for Acute Myeloid Leukemia: Current Strategies and Emerging Therapies (Keith W. Pratz and Judith E. Karp).
- 12. Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia (Gheath Alatrash and Marcos de Lima).
Part 4: Acute Promyelocytic Leukemia (APL).
- 13. The Pathophysiology of Acute Promyelocytic Leukemia (Francesco Lo-Coco and Syed Khizer Hasan).
- 14. Acute Promyelocytic Leukemia (APL): Manifestations and Therapy (Sylvain Thépot, Lionel Ades, Pierre Fenaux).
Part 5: Acute Lymphoblastic Leukemia (ALL).
- 15. Acute Lymphoblastic Leukemia: Presentation, Diagnosis and Classification (Sandeep Gurbuxani and John Anastasi).
- 16. Induction Therapy in Adult Acute Lymphoblastic Leukemia (Xavier Thomas).
- 17. Salvage Therapy of Adult Acute Lymphoblastic Leukemia (Nicola Gökbuget and Dieter Hoelzer).
- 18. Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Current Treatment Status and Perspectives (Olga Sala-Torra and Jerald P. Radich).
- 19. Acute Lymphoblastic Leukemia in Adolescents and Young Adults (Michael E. Rytting).
- 20. The Role of Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (Partow Kebriaei).
Part 6: Chronic Myeloid Leukemia (CML).
- 21. Pathophysiology of Chronic Myeloid Leukemia (Agnes S. M. Yong and Junia V. Melo).
- 22. Therapy of Newly Diagnosed and Chronic Phase Chronic Myelogenous Leukemia (Andreas Hochhaus).
- 23. Therapy of Advanced Stage and Resistant Chronic Myeloid Leukemia (Devendra K. Hiwase and Timothy P. Hughes).
Part 7: Chronic Lymphocytic Leukemia.
- 24. Chronic Lymphocytic Leukemia: Pathophysiology, Diagnosis and Manifestations, and Prognostic Markers (Thorsten Zenz, Hartmut Döhner, Stephan Stilgenbauer).
- 25. Therapy of Chronic Lymphocytic Leukemia – Frontline and Salvage (Valentin Goede, Barbara Eichhorst, and Michael Hallek).
- 26. The Role of Stem Cell Transplantation in Chronic Lymphocytic Leukemia (Simon Hallam and John G. Gribben).
- 27. Special Situations: Management of Elderly Patients and CLL Transformation (Wei-Gang Tong and Alessandra Ferrajoli).
Part 8: Other Leukemic Disorders.
- 28. Hairy Cell Leukemia (Farhad Ravandi).
- 29. Therapeutic Approaches to the Mature T-cell Lymphoproliferative Leukaemias (Nnenna Osuji and Claire Dearden).
- 30. Philadelphia Chromosome Negative Myeloproliferative Neoplasms (Ruben A. Mesa and Srdan Verstovsek).
Part 9: General Treatment Principles and Clinical Developments.
- 31. Management of Emergencies in Leukemias (Olga Frankfurt).
- 32. Management of Infectious Complications in Patients with Leukemia (Marcio Nucci, Nair Bijay and Elias Anaissie).
- 33. Transfusion Support and Hematopoietic Growth Factors (Paolo Rebulla).
- 34. New Designs for Clinical Trials: AML as an Example (Elihu Estey).
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