Immune Dysfunction and Immunotherapy in Heart Disease

DESCRIPTION

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.

The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension – makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.

The four parts of the book address:

· Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes
· Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs
· Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs
· Immune Dysfunction Leading to Heart Disease: Induction by Pathogens

Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Table of Contents

Contributors
Preface
About the Editors
Immune dysfunction leading to heart disease: induction by physiological changes 1
Immunosuppression by ultraviolet light-B radiation: a mediator of cardiac remodeling Sherma Zibadi Douglas F. Larson Ronald Ross Watson 3
Immune mechanisms in pediatric cardiovascular disease Wendy A. Luce Mandar S. Joshi Timothy M. Hoffman Timothy F. Feltes John Anthony Bauer 6
Heart failure-role of autoimmunity Urs Eriksson 17
Immune basis of hypertension in humans Katherine Horak Douglas F. Larson 28
Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodeling Sherma Zibadi Douglas F. Larson Ronald Ross Watson 34
T helper 2 cell cytokines in remodeling of aortic wall W. L Chan 39
Effects of TNF-[alpha] on cardiac function Bo Yang Douglas F. Larson 48
Immunosuppression in promotion of cardiac allograft vasculopathy Farzad Moien-Afshari Jonathan Choy Bruce M. McManus Ismail Laher 57
Immunotherapy forleft ventricular dysfunction after heart transplantation Charles E. Canter 80
Immune dysfunction promoting CVD: induction by transplantation drugs 95
Immunomodulating therapy in chronic heart failure Lars Gullestad Jan Kristian Damas Arne Yndestad Pal Aukrust 97
Statins in atherosclerosis: role of immune regulation Claire Arnaud Francois Mach 109
ACE inhibitors as immunomodulators: treatment of cardiovascular disease Christina Grothusen Bernhard Schieffer 116
Treatment of heart failure by anticytokine therapies Donna L. Vredevoe Julia R. Gage 128
Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs 133
Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome Giuseppe Barbaro 135
Cytokines and T cell-mediated responses in autoimmune myocarditis Jin Zhang 152
Drugs of abuse: accentuation of immunomodulation of viral myocarditis Oana Madalina Petrescu James P. Morgan 157
Immune dysfunction leading to heart disease: induction by pathogens 173
Osteopontin: the link between the immune system and cardiac remodeling Samira Najmaii Qianli Yu Douglas F. Larson 175
Inflammatory immune activation in heart failure patients: therapeutic implications Mohammad Abraham Kazemizadeh Gol Mohsen Araghi-Niknam 182
Role of innate immune dysregulation in diabetic heart failure Betsy B. Dokken Paul F. McDonagh 186
Tolerance in heart transplantation: current and future role Kimberly Gandy Jos Domen Jack Copeland 195
Neutralization of Th2 cytokines in therapy of cardiovascular pathology A. Mandel A. E. Bolton 207
Anti-inflammatory immune therapy in heart disease David Chen Christian Assad-Kottner Francisco J. Cordova Carlos Orrego Guillermo Torre-Amione 217
Cholesterol, interleukin-6 inflammation, and atherosclerosis-role of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of aging Sota Omoigui 227
Autoimmune myocarditis: treatment with anti-T-cell antibodies Zofia T. Bilinska Witold Ruzytto 256
Immunosuppressive therapy to counter cardiac allograft vasculopathy Carl V. Leier 263
Role of oral pathogens in the pathogenesis of coronary heart disease Palle Holmstrup 271
Myocardial regenerative potential by stem cell transplant Yinhong Chen Catherine A. Priest Joseph D. Gold 280
Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases Simin Bolourchi-Vaghefi Amy Galena 288
Index 301

AUTHOR INFORMATION

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center’s organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students.

Ronald Ross Watson Ph.D., Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 2850, Fax (520) 626 6093 rwatson@u.arizona.edu

Douglas F. Larson Ph.D., Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 6494 dflarson@email.arizona.edu