Outline of the Proposed Text An Introduction to Bacterial Pathogenesis: Molecular Mechanisms of Virulence and the Host Response 1.1. Introduction- Ecology and Epidemiology of Infection (incl. zoonoses). 2.1. Bacterial Virulence- Overview/Evolution of Pathogens 2.2. Bacterial Virulence- Adherence and Colonization 2.3. Bacterial Virulence- Invasion of Host Cells and Tissues. 2.4. Bacterial Virulence- Secretion of Virulence Factors. 2.5. Bacterial Virulence- Toxins. 2.6. Bacterial Virulence- Regulation of Virulence Factors. 2.7. Bacterial Virulence- Intracellular Pathogens. 2.8. Bacterial Virulence- Phase Variation and Biofilms 3.1. Immunity- Overview/Genetic Determinants of Susceptibility to Infection. 3.2. Innate Immunity- Normal Flora 3.3. Innate Immunity- Inflammatory Signal Transduction 3.4. Innate Immunity- Chemokines & Cytokines 3.5. Innate Immunity- Complement and Antimicrobial Peptides. 3.6. Innate Immunity- Nutritional/Metal Deprivation 3.7. Innate Immunity- Phagocytes and Oxygen-dependent Host Defenses 3.8. Adaptive Immunity- Humoral & Cellular Mechanisms 4.1. Specific Examples- Staphylococcus aureus. 4.2. Specific Examples- Coagulase-negative Staphylococci. 4.3. Specific Examples- Streptococcus pyogenes and other hemolytic streptococci. 4.4. Specific Examples- Streptococcus pneumoniae. 4.5. Specific Examples- Enterococcus. 4.6. Specific Examples- Listeria monocytogenes. 4.7. Specific Examples- Bacillus anthracis. 4.8. Specific Examples- Corynebacterium diphtheriae and diphtheroids. 4.9. Specific Examples- Escherichia coli (and sepsis). 4.10. Specific Examples- Shigella. 4.11. Specific Examples- Salmonella. 4.12. Specific Examples- Yersinia. 4.13. Specific Examples- Pseudomonas aeruginosa and related organisms. 4.14. Specific Examples- Haemophilus influenzae. 4.15. Specific Examples- Bordetella pertussis. 4.16. Specific Examples- Vibrio. 4.17. Specific Examples- Campylobacter. 4.18. Specific Examples- Helicobacter. 4.19. Specific Examples- Brucella. 4.20. Specific Examples- Francisella. 4.21. Specific Examples- Legionella. 4.22. Specific Examples- Bartonella. 4.23. Specific Examples- Neisseria. 4.24. Specific Examples- Clostridia. 4.25. Specific Examples- Bacteroides and Porphyromonas. 4.26. Specific Examples- Mycobacterium tuberculosis. 4.27. Specific Examples- Rickettsia. 4.28. Specific Examples- Chlamydia. 4.29. Specific Examples- Mycoplasma. 5.1. Conclusions- Importance of Antibiotic Resistance & Interactions with Virulence. 5.2. Conclusions- Biodefense 5.3. Conclusions- Methods of Studying Bacterial Pathogenesis 5.4. Conclusions- Our Wits versus Their Genes (Prospects for Future Approaches to Infection). Footnotes. Index
Designed to provide a balanced and up-to-date presentation of bacterial-host interactions, including both current paradigms and and areas of controversy. This book will highlight not only current knowledge but what is left to be discovered. The author presents in depth explanation of major concepts in an intelligent and accessible style while providing examples of clinical manifestation in boxes for interest and comprehension.
Ferric Fang is Professor of Microbiology at University of Washington. Dr. Fang Received his M.D. from Harvard Medical School and has held academic appointments at UC, San Diego and at the University of Colorado Health Sciences Center, Denver. He is currently an officer of the ASM.