Severe Acute Respiratory Syndrome

Prompting the first WHO global health alert for over a decade, Severe Acute Respiratory Syndrome (SARS) was first recognised in South-East Asia in February 2003.

With the causative agent now identified as a new strain of coronavirus, the medical world has gained important knowledge on the aetiology, clinical presentation, diagnosis, pathogenesis, epidemiology, disease treatment and infection control with amazing speed.

Despite this, major gaps remain in our understanding - the race is on to develop new cures and effective vaccines, and the long-term impact on health, society and economics are starting to unravel.

Severe Acute Respiratory Syndrome: A Clinical Guide meets the urgent need for a comprehensive, authoritative reference guide for everyone in the medical and scientific community engaged in the fight against SARS:

Definitive book on SARS, clearly and accurately documenting the extraordinary medical and scientific events around this new epidemic
International experts in the field, with many contributors from the WHO and CDC
Will help reader to understand and prevent future outbreaks with a repeat of the same consequences

Contents

Contributors, vii
Foreword, xi
Acknowledgements, xv

1 SARS: A Historical Perspective from Hong Kong
Kwok-yung Yuen and Nan-shan Zhong

2 SARS: A Global Perspective
David L Heymann

3 Clinical Presentation of the Disease in Adults
JY Sung and Kwok-yung Yuen

4 SARS in Children
CW Leung

5 SARS: Sequelae and Implications for Rehabilitation
David S Hui and Kenneth W Tsang

6 Radiology of SARS
Clara GC Ooi

7 Aetiology of SARS
Malik Peiris and Albert DME Osterhaus

8 Structure of the Genome of SARS CoV
Paul A Rota, Xin Liu, Byron T Cook and Suxiang Tong

9 Viral Diagnosis of SARS
C Drosten, KH Chan and LLM Poon

10 Pathology and Pathogenesis
JM Nicholls and T Kuiken

11 SARS Coronavirus: An Animal Reservoir?
Yi Guan, Hume Field, Gavin JD Smith and Honglin Chen

12 Comparative Biology of Animal Coronaviruses: Lessons for SARS
Linda J Saif

13 Epidemiology and Transmission of SARS
Angela Merianos, Robert Condon, Hitoshi Oshitani, Denise Werker and Roberta Andraghetti

14 Transmission Dynamics and Control of the Viral Aetiological Agent of SARS
Gabriel M Leung, Anthony J Hedley, Tai Hing Lam, Azra C Ghani, Christl A Donnelly, Christophe Fraser, Steven Riley, Neil M Ferguson and Roy M Anderson

15 The Seasonality of Respiratory Virus Diseases: Implications for SARS?
JC de Jong and WL Lim

16 Public Health Response: A View from Singapore
Chorh Chuan Tan

17 Public Health Response: A View from Hong Kong
T Tsang

18 Public Health Response: A View from a Region with a Low Incidence of SARS
James W LeDuc

19 Infection Control for SARS: Causes of Success and Failure
WH Seto, PTY Ching and PL Ho

20 Antiviral Agents for SARS
Frederick G Hayden and Mark R Denison

21 Vaccines
Kanta Subbarao

22 Counting the Economic Cost of SARS
YC Richard Wong and Alan Siu

23 Preparing for a Possible Resurgence of SARS
Umesh D Parashar, Angela Merianos, Cathy Roth and Larry J Anderson

24 Lessons for the Future: Pandemic Influenza
Robert G Webster and David S Fedson

25 Lessons Learnt
Albert DME Osterhaus and Malik Peiris

Appendix
Index
Colour plate facing page